Normal view MARC view ISBD view

Thrombotic Microangiopathies (TTP, HUS, HELLP). [Review] - 2017

Available online from MWHC library: 1996 - present

Copyright (c) 2017 Elsevier Inc. All rights reserved. Thrombocytopenia, strictly defined as a platelet count less than 150,000, is common in the emergency department. Recognition, diagnostic investigation, and proper disposition of a thrombocytopenic patient are imperative. One group of disorders leading to thrombocytopenia is the thrombotic microangiopathies, hallmarked by platelet destruction. These thrombotic microangiopathies include thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS) and hemolysis, elevated liver enzyme levels, low platelet count (HELLP), which should be distinguished from similar disease processes such as immune thrombocytopenia (ITP), disseminated intravascular coagulation (DIC) and heparin induced thrombocytopenia (HIT). In this article, clinical presentations, pathophysiology, diagnostic workup, management plans, complications, and dispositions are addressed for this complex group of platelet disorders.


English

ISSN: 0889-8588

Subjects--Topical Terms:
*Emergency Medical Services/mt [Methods]
*Thrombotic Microangiopathies
Disseminated Intravascular Coagulation/bl [Blood]
Disseminated Intravascular Coagulation/di [Diagnosis]
Disseminated Intravascular Coagulation/pp [Physiopathology]
Disseminated Intravascular Coagulation/th [Therapy]
Humans
Platelet Count
Purpura, Thrombocytopenic, Idiopathic/bl [Blood]
Purpura, Thrombocytopenic, Idiopathic/di [Diagnosis]
Purpura, Thrombocytopenic, Idiopathic/pp [Physiopathology]
Purpura, Thrombocytopenic, Idiopathic/th [Therapy]
Thrombotic Microangiopathies/bl [Blood]
Thrombotic Microangiopathies/di [Diagnosis]
Thrombotic Microangiopathies/pp [Physiopathology]
Thrombotic Microangiopathies/th [Therapy]

Subjects--Geographic Terms:
MedStar Washington Hospital Center

Index Terms--Occupation:
Emergency Medicine

Index Terms--Function:
Journal Article
Review