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Thrombotic Microangiopathies (TTP, HUS, HELLP). [Review]

MedStar author(s):

Citation: Hematology - Oncology Clinics of North America. 31(6):1081-1103, 2017 DecPMID: 29078925Institution: MedStar Washington Hospital CenterDepartment: Emergency MedicineForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Emergency Medical Services/mt [Methods] | *Thrombotic Microangiopathies | Disseminated Intravascular Coagulation/bl [Blood] | Disseminated Intravascular Coagulation/di [Diagnosis] | Disseminated Intravascular Coagulation/pp [Physiopathology] | Disseminated Intravascular Coagulation/th [Therapy] | Humans | Platelet Count | Purpura, Thrombocytopenic, Idiopathic/bl [Blood] | Purpura, Thrombocytopenic, Idiopathic/di [Diagnosis] | Purpura, Thrombocytopenic, Idiopathic/pp [Physiopathology] | Purpura, Thrombocytopenic, Idiopathic/th [Therapy] | Thrombotic Microangiopathies/bl [Blood] | Thrombotic Microangiopathies/di [Diagnosis] | Thrombotic Microangiopathies/pp [Physiopathology] | Thrombotic Microangiopathies/th [Therapy]Year: 2017 Local holdings: Available online from MWHC library: 1996 - presentISSN:

0889-8588

Name of journal: Hematology/oncology clinics of North AmericaAbstract: Copyright (c) 2017 Elsevier Inc. All rights reserved.Thrombocytopenia, strictly defined as a platelet count less than 150,000, is common in the emergency department. Recognition, diagnostic investigation, and proper disposition of a thrombocytopenic patient are imperative. One group of disorders leading to thrombocytopenia is the thrombotic microangiopathies, hallmarked by platelet destruction. These thrombotic microangiopathies include thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS) and hemolysis, elevated liver enzyme levels, low platelet count (HELLP), which should be distinguished from similar disease processes such as immune thrombocytopenia (ITP), disseminated intravascular coagulation (DIC) and heparin induced thrombocytopenia (HIT). In this article, clinical presentations, pathophysiology, diagnostic workup, management plans, complications, and dispositions are addressed for this complex group of platelet disorders.All authors: Graham A, Kappler S, Ronan-Bentle SFiscal year: FY2018Digital Object Identifier:

https://dx.doi.org/10.1016/j.hoc.2017.08.010

Date added to catalog: 2017-11-10

Holdings ( 1 )
Title notes ( 4 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	29078925	Available		29078925

Available online from MWHC library: 1996 - present

Thrombocytopenia, strictly defined as a platelet count less than 150,000, is common in the emergency department. Recognition, diagnostic investigation, and proper disposition of a thrombocytopenic patient are imperative. One group of disorders leading to thrombocytopenia is the thrombotic microangiopathies, hallmarked by platelet destruction. These thrombotic microangiopathies include thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS) and hemolysis, elevated liver enzyme levels, low platelet count (HELLP), which should be distinguished from similar disease processes such as immune thrombocytopenia (ITP), disseminated intravascular coagulation (DIC) and heparin induced thrombocytopenia (HIT). In this article, clinical presentations, pathophysiology, diagnostic workup, management plans, complications, and dispositions are addressed for this complex group of platelet disorders.

English