The Potential of Gelam Honey in Promoting the Proliferative Phase of Corneal Reepithelialization.
The Potential of Gelam Honey in Promoting the Proliferative Phase of Corneal Reepithelialization.
- 2017
CONCLUSIONS: Although a minor improvement of weekly healing rate was seen for a subset of the wounds, the overall wound closure rate was low. INTRODUCTION: Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden. MATERIALS AND METHODS: All patients in the study were treated with a topical gel along with standard of care modalities. OBJECTIVE: This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy. RESULTS: A total of 48 patients with 76 wounds (50/76 venous leg ulcers; 65.8%) were identi ed and analyzed. Of the 48 patients, 11 (22.9%) had complete wound closure at a mean of 101.6 days of treatment. The number of wounds decreasing in size improved from 45.3% to 77.6% after gel therapy. An analysis of all wounds showed an increase in size by 0.7% weekly with the topical gel; how- ever, a mean weekly healing rate of 6.5% was seen when analyzing only the subset of wounds that decreased in size.
English
1044-7946
WNDS20170926-3 [pii]
*Anti-Infective Agents
*Cell Proliferation/de [Drug Effects]
*Epithelium, Corneal/de [Drug Effects]
*Honey
*Re-Epithelialization/de [Drug Effects]
*Wound Healing/ph [Physiology]
Anti-Infective Agents/pd [Pharmacology]
Cell Proliferation/ph [Physiology]
Epithelium, Corneal/in [Injuries]
Epithelium, Corneal/pa [Pathology]
Female
Gene Expression
Humans
Male
Organ Culture Techniques
Re-Epithelialization/ph [Physiology]
Retrospective Studies
Treatment Outcome
MedStar Washington Hospital Center
Surgery/Podiatric Surgery
Journal Article
CONCLUSIONS: Although a minor improvement of weekly healing rate was seen for a subset of the wounds, the overall wound closure rate was low. INTRODUCTION: Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden. MATERIALS AND METHODS: All patients in the study were treated with a topical gel along with standard of care modalities. OBJECTIVE: This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy. RESULTS: A total of 48 patients with 76 wounds (50/76 venous leg ulcers; 65.8%) were identi ed and analyzed. Of the 48 patients, 11 (22.9%) had complete wound closure at a mean of 101.6 days of treatment. The number of wounds decreasing in size improved from 45.3% to 77.6% after gel therapy. An analysis of all wounds showed an increase in size by 0.7% weekly with the topical gel; how- ever, a mean weekly healing rate of 6.5% was seen when analyzing only the subset of wounds that decreased in size.
English
1044-7946
WNDS20170926-3 [pii]
*Anti-Infective Agents
*Cell Proliferation/de [Drug Effects]
*Epithelium, Corneal/de [Drug Effects]
*Honey
*Re-Epithelialization/de [Drug Effects]
*Wound Healing/ph [Physiology]
Anti-Infective Agents/pd [Pharmacology]
Cell Proliferation/ph [Physiology]
Epithelium, Corneal/in [Injuries]
Epithelium, Corneal/pa [Pathology]
Female
Gene Expression
Humans
Male
Organ Culture Techniques
Re-Epithelialization/ph [Physiology]
Retrospective Studies
Treatment Outcome
MedStar Washington Hospital Center
Surgery/Podiatric Surgery
Journal Article