The Potential of Gelam Honey in Promoting the Proliferative Phase of Corneal Reepithelialization.

MedStar author(s):
Citation: Wounds-A Compendium of Clinical Research & Practice. 29(12):380-386, 2017 DecPMID: 28976341Institution: MedStar Washington Hospital CenterDepartment: Surgery/Podiatric SurgeryForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Anti-Infective Agents | *Cell Proliferation/de [Drug Effects] | *Epithelium, Corneal/de [Drug Effects] | *Honey | *Re-Epithelialization/de [Drug Effects] | *Wound Healing/ph [Physiology] | Anti-Infective Agents/pd [Pharmacology] | Cell Proliferation/ph [Physiology] | Epithelium, Corneal/in [Injuries] | Epithelium, Corneal/pa [Pathology] | Female | Gene Expression | Humans | Male | Organ Culture Techniques | Re-Epithelialization/ph [Physiology] | Retrospective Studies | Treatment OutcomeYear: 2017ISSN:
  • 1044-7946
Name of journal: Wounds : a compendium of clinical research and practiceAbstract: CONCLUSIONS: Although a minor improvement of weekly healing rate was seen for a subset of the wounds, the overall wound closure rate was low.INTRODUCTION: Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden.MATERIALS AND METHODS: All patients in the study were treated with a topical gel along with standard of care modalities.OBJECTIVE: This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy.RESULTS: A total of 48 patients with 76 wounds (50/76 venous leg ulcers; 65.8%) were identi ed and analyzed. Of the 48 patients, 11 (22.9%) had complete wound closure at a mean of 101.6 days of treatment. The number of wounds decreasing in size improved from 45.3% to 77.6% after gel therapy. An analysis of all wounds showed an increase in size by 0.7% weekly with the topical gel; how- ever, a mean weekly healing rate of 6.5% was seen when analyzing only the subset of wounds that decreased in size.All authors: Attinger CE, Benkert EA, Evans KK, Kim PJ, Oliver NG, Rocha ZM, Steinberg JS, Zarick CSFiscal year: FY2018Date added to catalog: 2018-01-22
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Journal Article MedStar Authors Catalog Article 28976341 Available 28976341

CONCLUSIONS: Although a minor improvement of weekly healing rate was seen for a subset of the wounds, the overall wound closure rate was low.

INTRODUCTION: Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden.

MATERIALS AND METHODS: All patients in the study were treated with a topical gel along with standard of care modalities.

OBJECTIVE: This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy.

RESULTS: A total of 48 patients with 76 wounds (50/76 venous leg ulcers; 65.8%) were identi ed and analyzed. Of the 48 patients, 11 (22.9%) had complete wound closure at a mean of 101.6 days of treatment. The number of wounds decreasing in size improved from 45.3% to 77.6% after gel therapy. An analysis of all wounds showed an increase in size by 0.7% weekly with the topical gel; how- ever, a mean weekly healing rate of 6.5% was seen when analyzing only the subset of wounds that decreased in size.

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