Effectiveness of a Glycylcycline Antibiotic for Reducing the Pathogenicity of Superantigen-Producing Methicillin-Resistant Staphylococcus aureus in Burn Wounds. (Record no. 2717)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03120nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170929s20172017 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1937-5719 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 28943993 |
| 245 ## - TITLE STATEMENT | |
| Title | Effectiveness of a Glycylcycline Antibiotic for Reducing the Pathogenicity of Superantigen-Producing Methicillin-Resistant Staphylococcus aureus in Burn Wounds. |
| 251 ## - Source | |
| Source | Eplasty [Electronic Resource]. 17:e27, 2017 |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Eplasty. 17:e27, 2017 |
| 253 ## - Journal Name | |
| Journal name | Eplasty |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2017 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2018 |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2017-09-29 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | <b>Objective</b>: Burn-injured patients are highly susceptible to infectious complications, which are often associated with increased morbidity and mortality. Rates of antibiotic resistance have increased, and resistant species such as methicillin-resistant Staphylococcus aureus provide additional challenges in the form of virulence factors. Proteins can disrupt local healing, leading to systemic immune disruption. To optimize outcomes, treatments that reduce pathogenicity must be identified. This study aims to compare a glycylcycline antibiotic-tigecycline-with clindamycin for effectiveness in treating superantigenic methicillin-resistant Staphylococcus aureus in burn wounds. <b>Methods</b>: Sprague-Dawley rats received paired 2 x 2-cm burn wounds, which were subsequently inoculated with known virulence factor-producing methicillin-resistant Staphylococcus aureus or media alone on postinjury day 1. Infected animals received twice-daily tigecycline (high or low dose), twice-daily clindamycin (high or low dose), or saline alone (positive controls). Daily sampling and imaging assessments were performed. <b>Results</b>: Bacterial counts and toxin levels were reduced significantly in antibiotic-treated groups relative to positive controls (P < .001). Results from day 7 showed measurable toxin levels in clindamycin-treated, but not tigecycline-treated, wounds. Imaging analysis revealed a return of wound perfusion in tigecycline-treated animals similar to the sham animals. Transcript analysis using polymerase chain reaction and polymerase chain reaction arrays demonstrated downregulation of gene expression in antibiotic-treated animals as compared with positive controls. <b>Conclusions</b>: Overall, this study supports the use of tigecycline in the treatment of methicillin-resistant Staphylococcus aureus-infected burn wounds. While both protein synthesis inhibitors are effective, tigecycline appears to be superior in controlling toxin levels, enabling better wound healing. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PubMed-not-MEDLINE -- Not indexed |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Surgery/Burn Services |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Carney, Bonnie C |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Jo, Daniel Y |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Moffatt, Lauren T |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Nosanov, Lauren B |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Ortiz, Rachel T T |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Randad, Pranay R |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Shupp, Jeffrey W |
| 790 ## - Authors | |
| All authors | Carney BC, Jo DY, Moffatt LT, Nosanov LB, Ortiz RT, Randad PR, Shupp JW |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MedStar Authors Catalog | MedStar Authors Catalog | 09/29/2017 | 28943993 | 28943993 | 09/29/2017 | 09/29/2017 | Journal Article |