MARC details
| 000 -LEADER |
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| fixed length control field |
03814nam a22003617a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190724s20182018 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0732-183X |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1200/JCO.18.00140 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
30281396 |
| 245 ## - TITLE STATEMENT |
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| Title |
Cancer-Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study. |
| 251 ## - Source |
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| Source |
Journal of Clinical Oncology. :JCO1800140, 2018 Oct 03 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
J Clin Oncol. :JCO1800140, 2018 Oct 03 |
| 253 ## - Journal Name |
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| Journal name |
Journal of clinical oncology : official journal of the American Society of Clinical Oncology |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2018 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2019 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2018-10-10 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: 1999 - present, Available in print through MWHC library: 1999 - 2008 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSION: Breast cancer systemic treatment and aging-related phenotypes and genotypes are associated with longitudinal decreases in cognitive function scores in older survivors. These data could inform treatment decision making and survivorship care planning. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: Newly diagnosed nonmetastatic breast cancer survivors (n = 344) and matched controls without cancer (n = 347) 60 years of age and older without dementia or neurologic disease were recruited between August 2010 and December 2015. Data collection occurred during presystemic treatment/control enrollment and at 12 and 24 months through biospecimens; surveys; self-reported Functional Assessment of Cancer Therapy-Cognitive Function; and neuropsychological tests that measured attention, processing speed, and executive function (APE) and learning and memory (LM). Linear mixed-effects models tested two-way interactions of treatment group (control, chemotherapy with or without hormonal therapy, and hormonal therapy) and time and explored three-way interactions of ApoE (epsilon4+ v not) by group by time; covariates included baseline age, frailty, race, and cognitive reserve. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
PURPOSE: To determine treatment and aging-related effects on longitudinal cognitive function in older breast cancer survivors. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: Survivors and controls were 60 to 98 years of age, were well educated, and had similar baseline cognitive scores. Treatment was related to longitudinal cognition scores, with survivors who received chemotherapy having increasingly worse APE scores ( P = .05) and those initiating hormonal therapy having lower LM scores at 12 months ( P = .03) than other groups. These group-by-time differences varied by ApoE genotype, where only epsilon4+ survivors receiving hormone therapy had short-term decreases in adjusted LM scores (three-way interaction P = .03). For APE, the three-way interaction was not significant ( P = .14), but scores were significantly lower for epsilon4+ survivors exposed to chemotherapy (-0.40; 95% CI, -0.79 to -0.01) at 24 months than epsilon4+ controls (0.01; 95% CI, 0.16 to 0.18; P < .05). Increasing age was associated with lower baseline scores on all cognitive measures ( P < .001); frailty was associated with baseline APE and self-reported decline ( P < .001). |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Hematology and Oncology |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Dilawari, Asma |
| 790 ## - Authors |
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| All authors |
Ahles T, Breen E, Carroll JE, Clapp J, Denduluri N, Dilawari A, Extermann M, Graham D, Holohan Nudelman K, Hurria A, Isaacs C, Jacobsen PB, Jim H, Kobayashi LC, Luta G, Mandelblatt JS, McDonald BC, Root J, Saykin AJ, Small BJ, Stern RA, Tometich D, Turner R, VanMeter JW, Zhai W, Zhou X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1200/JCO.18.00140">https://dx.doi.org/10.1200/JCO.18.00140</a> |
| Public note |
https://dx.doi.org/10.1200/JCO.18.00140 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
