Conus involvement and leptomeningeal enhancement in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: A case report. (Record no. 6417)

MARC details
000 -LEADER
fixed length control field 02384nam a22003737a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210628s20212021 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 2211-0348
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1016/j.msard.2021.103011 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code S2211-0348(21)00278-9 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 34015641
245 ## - TITLE STATEMENT
Title Conus involvement and leptomeningeal enhancement in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: A case report.
251 ## - Source
Source Multiple Sclerosis and Related Disorders. 52:103011, 2021 May 07.
252 ## - Abbreviated Source
Abbreviated source Mult Scler Relat Disord. 52:103011, 2021 May 07.
253 ## - Journal Name
Journal name Multiple sclerosis and related disorders
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2021
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2021
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Publication date 2021 May 07
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status aheadofprint
266 ## - Date added to catalog
Date added to catalog 2021-06-28
520 ## - SUMMARY, ETC.
Abstract There are a variety of clinical phenotypes and radiological features that continue to make a diagnosis of neuromyelitis optica spectrum disorder (NMOSD) challenging. We present an atypical case of an adult woman who presented with flaccid paralysis of all extremities with unusual neuroimaging features, including extensive enhancing lesions in the upper cervical cord and conus medullaris with associated leptomeningeal enhancement. She was ultimately found to have AQP4 antibody-positive NMOSD. We discuss the factors that complicated a timely diagnosis, including her atypical radiographic features and an initially negative cell-based assay for myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) antibodies. Despite the rarity of conus medullaris involvement or leptomeningeal enhancement in AQP4 antibody-positive NMOSD, it is important to maintain a high level of clinical suspicion to avoid diagnostic and therapeutic delays. Though cell-based assays have high sensitivities, testing should be repeated on negative values in these scenarios. Copyright (c) 2021 Elsevier B.V. All rights reserved.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN PROCESS -- NOT YET INDEXED
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Washington Hospital Center
656 ## - INDEX TERM--OCCUPATION
Department Neurology
656 ## - INDEX TERM--OCCUPATION
Department Neurology Residency
657 ## - INDEX TERM--FUNCTION
Medline publication type Letter
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Hu, Nancy
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Myers, Cory
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Safadi, Amy
790 ## - Authors
All authors Hu NN, Myers CJ, Osborne B, Safadi AL
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1016/j.msard.2021.103011">https://dx.doi.org/10.1016/j.msard.2021.103011</a>
Public note https://dx.doi.org/10.1016/j.msard.2021.103011
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 06/28/2021   34015641 34015641 06/28/2021 06/28/2021 Journal Article

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