Conus involvement and leptomeningeal enhancement in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: A case report. (Record no. 6417)
[ view plain ]
000 -LEADER | |
---|---|
fixed length control field | 02384nam a22003737a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 210628s20212021 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
International Standard Serial Number | 2211-0348 |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1016/j.msard.2021.103011 [doi] |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | S2211-0348(21)00278-9 [pii] |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
PMID | 34015641 |
245 ## - TITLE STATEMENT | |
Title | Conus involvement and leptomeningeal enhancement in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: A case report. |
251 ## - Source | |
Source | Multiple Sclerosis and Related Disorders. 52:103011, 2021 May 07. |
252 ## - Abbreviated Source | |
Abbreviated source | Mult Scler Relat Disord. 52:103011, 2021 May 07. |
253 ## - Journal Name | |
Journal name | Multiple sclerosis and related disorders |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Year | 2021 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Manufacturer | FY2021 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Publication date | 2021 May 07 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
Publication status | aheadofprint |
266 ## - Date added to catalog | |
Date added to catalog | 2021-06-28 |
520 ## - SUMMARY, ETC. | |
Abstract | There are a variety of clinical phenotypes and radiological features that continue to make a diagnosis of neuromyelitis optica spectrum disorder (NMOSD) challenging. We present an atypical case of an adult woman who presented with flaccid paralysis of all extremities with unusual neuroimaging features, including extensive enhancing lesions in the upper cervical cord and conus medullaris with associated leptomeningeal enhancement. She was ultimately found to have AQP4 antibody-positive NMOSD. We discuss the factors that complicated a timely diagnosis, including her atypical radiographic features and an initially negative cell-based assay for myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) antibodies. Despite the rarity of conus medullaris involvement or leptomeningeal enhancement in AQP4 antibody-positive NMOSD, it is important to maintain a high level of clinical suspicion to avoid diagnostic and therapeutic delays. Though cell-based assays have high sensitivities, testing should be repeated on negative values in these scenarios. Copyright (c) 2021 Elsevier B.V. All rights reserved. |
546 ## - LANGUAGE NOTE | |
Language note | English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
Institution | MedStar Washington Hospital Center |
656 ## - INDEX TERM--OCCUPATION | |
Department | Neurology |
656 ## - INDEX TERM--OCCUPATION | |
Department | Neurology Residency |
657 ## - INDEX TERM--FUNCTION | |
Medline publication type | Letter |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Hu, Nancy |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Myers, Cory |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Safadi, Amy |
790 ## - Authors | |
All authors | Hu NN, Myers CJ, Osborne B, Safadi AL |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
DOI | <a href="https://dx.doi.org/10.1016/j.msard.2021.103011">https://dx.doi.org/10.1016/j.msard.2021.103011</a> |
Public note | https://dx.doi.org/10.1016/j.msard.2021.103011 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Koha item type | Journal Article |
Item type description | Article |
Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MedStar Authors Catalog | MedStar Authors Catalog | 06/28/2021 | 34015641 | 34015641 | 06/28/2021 | 06/28/2021 | Journal Article |