MedStar Authors catalog › Details for: Isolated diastolic hypertension and incident heart failure in community-dwelling older adults: Insights from the Cardiovascular Health Study.
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Isolated diastolic hypertension and incident heart failure in community-dwelling older adults: Insights from the Cardiovascular Health Study.

by Tsimploulis, Apostolos.
Citation: International Journal of Cardiology. , 2017 Mar 01.Journal: International journal of cardiology.Published: 2017ISSN: 0167-5273.Full author list: Sheriff HM; Tsimploulis A; Valentova M; Anker MS; Deedwania P; Banach M; Morgan CJ; Blackman MR; Fonarow GC; White M; Alagiakrishnan K; Allman RM; Aronow WS; Anker SD; Ahmed A.UI/PMID: 28343761.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Washington Hospital CenterDepartment(s): Medicine/Internal MedicineActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: https://dx.doi.org/10.1016/j.ijcard.2017.02.142 (Click here) Abbreviated citation: Int J Cardiol. , 2017 Mar 01.Abstract: BACKGROUND: Isolated systolic hypertension and isolated diastolic hypotension are common in older adults and associated with a higher risk of incident heart failure (HF). However, little is known about the prevalence and impact of isolated diastolic hypertension in this population.Abstract: METHODS: In the Cardiovascular Health Study (CHS), of the 5776 community-dwelling older adults >65years who had data on baseline systolic and diastolic blood pressure (SBP and DBP), 28 had isolated diastolic hypertension (DBP >90mmHg and SBP <140mmHg). From the 5748 without isolated diastolic hypertension, we excluded those with SBP >120mmHg (n=4451), DBP 80-89mmHg (n=20), DBP <60mmHg (n=425), normal BP taking anti-hypertensive medications (n=311), normal BP taking no anti-hypertensive medications but with history of hypertension (n=38), and baseline HF (n=5). The final cohort of 524 participants included 27 with isolated diastolic hypertension.Abstract: RESULTS: Patients (n=524) had a mean (+/-SD) age of 71 (+/-5) years, 58% were women and 9% African American. There were no significant between-group age or sex differences; 37% of those with isolated diastolic hypertension (versus 7% without) were African American. Incident HF occurred in 19% and 7% of participants with and without isolated diastolic hypertension, respectively (multivariable-adjusted hazard ratio {HR}, 4.65; 95% confidence interval {CI}, 1.09-19.90; p=0.038). There was a trend toward higher cardiovascular mortality (HR, 4.59; 95% CI, 0.92-23.88; p=0.063).Abstract: CONCLUSION: Among community-dwelling older adults, isolated diastolic hypertension is rare and is associated with higher risk for incident HF and cardiovascular mortality.Abstract: Copyright Published by Elsevier B.V.

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