My Bleeding Nephrons!.

MedStar author(s):
Citation: Journal of Investigative Medicine High Impact Case Reports. 7:2324709619858126, 2019 Jan-Dec.PMID: 31216916Institution: MedStar Washington Hospital CenterDepartment: Medicine/Internal MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Acute Kidney Injury/et [Etiology] | *Anticoagulants/ae [Adverse Effects] | *Glomerulonephritis, IGA/co [Complications] | *Kidney Glomerulus/pa [Pathology] | *Warfarin/ae [Adverse Effects] | Acute Kidney Injury/pa [Pathology] | Aged | Glomerulonephritis, IGA/di [Diagnosis] | Glomerulonephritis, IGA/pa [Pathology] | Hematuria/et [Etiology] | Humans | International Normalized Ratio | Kidney Glomerulus/de [Drug Effects] | Kidney/bs [Blood Supply] | Male | Renal Insufficiency, Chronic/ci [Chemically Induced] | Renal Insufficiency, Chronic/pp [Physiopathology] | Risk FactorsYear: 2019ISSN:
  • 2324-7096
Name of journal: Journal of investigative medicine high impact case reportsAbstract: Anticoagulation-related nephropathy (ARN) is an uncommon diagnosis that should be considered in patients presenting with unexplained acute kidney injury (AKI) and coagulopathy. In this article, we present the case of a 70-year-old male with a history of cirrhosis and portal vein thrombosis on Coumadin who presented to the hospital with gross hematuria. The patient was diagnosed with AKI on chronic kidney disease (CKD) secondary to ARN superimposed on sclerosing IgA nephropathy. ARN, also known as warfarin-associated nephropathy, is an uncommon condition in which AKI from glomerular hemorrhage develops in a patient with an international normalized ratio greater than 3. The most common risk factor for development of ARN is CKD. AKI in our patient unearthed preexisting CKD due to IgA nephropathy as evidenced by the biopsy.All authors: Hinnant G, Li J, Mohammed A, Padala SA, Vakiti AOriginally published: Journal of Investigative Medicine High Impact Case Reports. 7:2324709619858126, 2019 Jan-Dec.Fiscal year: FY2019Digital Object Identifier: Date added to catalog: 2019-07-24
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Journal Article MedStar Authors Catalog Article 31216916 Available 31216916

Anticoagulation-related nephropathy (ARN) is an uncommon diagnosis that should be considered in patients presenting with unexplained acute kidney injury (AKI) and coagulopathy. In this article, we present the case of a 70-year-old male with a history of cirrhosis and portal vein thrombosis on Coumadin who presented to the hospital with gross hematuria. The patient was diagnosed with AKI on chronic kidney disease (CKD) secondary to ARN superimposed on sclerosing IgA nephropathy. ARN, also known as warfarin-associated nephropathy, is an uncommon condition in which AKI from glomerular hemorrhage develops in a patient with an international normalized ratio greater than 3. The most common risk factor for development of ARN is CKD. AKI in our patient unearthed preexisting CKD due to IgA nephropathy as evidenced by the biopsy.

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