Intravascular large B-cell lymphoma presenting as multiple stroke: A case report.

MedStar author(s):
Citation: Medicine. 97(41):e12793, 2018 Oct.PMID: 30313105Institution: Medstar Franklin Square Medical CenterDepartment: Pulmonary and Critical Care MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Lymphoma, Large B-Cell, Diffuse/di [Diagnosis] | *Lymphoma, Large B-Cell, Diffuse/pa [Pathology] | *Stroke/di [Diagnosis] | *Stroke/pa [Pathology] | *Vascular Neoplasms/di [Diagnosis] | *Vascular Neoplasms/pa [Pathology] | Antibodies, Monoclonal, Murine-Derived | Antineoplastic Combined Chemotherapy Protocols | Cyclophosphamide | Diagnosis, Differential | Doxorubicin | Female | Humans | Lymphoma, Large B-Cell, Diffuse/dt [Drug Therapy] | Middle Aged | Prednisone | Vascular Neoplasms/dt [Drug Therapy] | VincristineYear: 2018Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006ISSN:
  • 0025-7974
Name of journal: MedicineAbstract: CASE PRESENTATION: We report an interesting case of IVLBCL presenting as bilateral strokes. The diagnosis was made by a random skin biopsy, which confirmed IVLBCL. The patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP).Neurological symptoms improved with R-CHOP. Repeat magnetic resonance imaging (MRI) of the brain showed improvement of the prior lesions.CONCLUSION: IVLBCL is an aggressive disease with high mortality. Timely diagnosis and treatment can be lifesaving.INTRODUCTION: Intravascular large B-cell lymphoma (IVLBCL) is an uncommon disease with a poor prognosis if not diagnosed early. It can present with central nervous system (CNS) manifestations. The diagnosis of IVCBCL is difficult to make given its varied clinical manifestations and the lack of a specific diagnostic modality.All authors: Muganlinskaya N, Selinger S, Yunce MFiscal year: FY2019Digital Object Identifier: Date added to catalog: 2018-11-02
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 30313105 Available 30313105

Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006

CASE PRESENTATION: We report an interesting case of IVLBCL presenting as bilateral strokes. The diagnosis was made by a random skin biopsy, which confirmed IVLBCL. The patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP).Neurological symptoms improved with R-CHOP. Repeat magnetic resonance imaging (MRI) of the brain showed improvement of the prior lesions.

CONCLUSION: IVLBCL is an aggressive disease with high mortality. Timely diagnosis and treatment can be lifesaving.

INTRODUCTION: Intravascular large B-cell lymphoma (IVLBCL) is an uncommon disease with a poor prognosis if not diagnosed early. It can present with central nervous system (CNS) manifestations. The diagnosis of IVCBCL is difficult to make given its varied clinical manifestations and the lack of a specific diagnostic modality.

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