Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report.
Citation: BMC Endocrine Disorders. 21(1):221, 2021 Nov 04.PMID: 34736430Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Case Reports | Journal ArticleSubject headings: *Adenocarcinoma, Follicular/sc [Secondary] | *Bone Neoplasms/sc [Secondary] | *Thyroid Neoplasms/pa [Pathology] | *Thyroid Nodule/pa [Pathology] | Adenocarcinoma, Follicular/dg [Diagnostic Imaging] | Adenocarcinoma, Follicular/rt [Radiotherapy] | Adult | Bone Neoplasms/dg [Diagnostic Imaging] | Bone Neoplasms/rt [Radiotherapy] | Cell Nucleus/pa [Pathology] | Female | Humans | Ilium/dg [Diagnostic Imaging] | Iodine Radioisotopes/tu [Therapeutic Use] | Single Photon Emission Computed Tomography Computed Tomography | Thyroid Cancer, Papillary/pa [Pathology] | Thyroid Neoplasms/su [Surgery] | Thyroid Nodule/su [Surgery] | Thyroidectomy | Tomography, X-Ray ComputedYear: 2021Local holdings: Available online from MWHC library: 2001 - presentISSN:- 1472-6823
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 34736430 | Available | 34736430 |
Available online from MWHC library: 2001 - present
BACKGROUND: The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed as a non-malignant thyroid lesion with indolent behavior that does not require post-operative radio-iodine treatment. We are reporting a case of NIFTP with bone metastasis that is the second case reported so far.
CASE PRESENTATION: We describe a 38-year-old woman who presented with an indeterminate thyroid nodule and underwent total thyroidectomy with the finding of NIFTP on careful pathologic examination. However, her initial follow-up evaluation revealed a serum thyroglobulin level of > 300 ng/ml and a diagnostic whole body 131I scan demonstrated a focus of increased uptake in the left hemipelvis, confirmed on CT scan to be a lytic lesion in the left iliac bone. She was treated with 7.4GBq (200 mCi) of 131I and her follow-up 1 year later revealed an undetectable serum thyroglobulin and a negative whole body 131I scan with no visible uptake in the iliac bone indicating an excellent response.
CONCLUSION: This case presentation reminds us to be alert to the rare occurrence of distant metastasis in NIFTP and the need for a case by case analysis and continuing post-operative follow-up for detection of residual or recurrent disease. Copyright © 2021. The Author(s).
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