Fetal development in women with diabetes: imprinting for a life-time?.
Fetal development in women with diabetes: imprinting for a life-time?.
Available online through MWHC library: 2013 to the present
CONCLUSION: The hyperglycemic intrauterine environment is associated with short-term morbidity, manifested as asymmetric LGA (the "fat" baby). In addition, increasing level of maternal hyperglycemia during pregnancy is associated with increased adiposity and elevated fasting glucose in the young adult offspring. METHODS: We report findings from a feasibility study on 19 young adults, born to mothers with type 1 diabetes. Long-term follow-up of the offspring in young adulthood included: oral glucose tolerance test, body mass index (BMI), dual X-ray absorptiometry, and blood pressure (BP). We report z-BMI and z-BP to account for varying gender and age. OBJECTIVE: To test the hypothesis that fetal exposure to a hyperglycemic intrauterine environment in women with type 1 diabetes is associated with asymmetrically distributed excessive fetal growth and imprinting consistent with adverse health issues later in life. RESULTS: The young adults born to women with diabetes averaged 19.9 years at follow-up; 37% were female, and 21% African American. Maternal glycohemoglobin A(1) concentration in the 2nd trimester was 9.2% for offspring born with asymmetric LGA and 7.5% for those born with symmetric LGA or AGA. There was significant correlation between maternal glucose control during pregnancy and fasting glucose, z-BMI and z-systolic BP in the young adults.
English
1476-4954
*Diabetes Mellitus, Type 1/co [Complications]
*Pregnancy in Diabetics
*Prenatal Exposure Delayed Effects
Absorptiometry, Photon
Adiposity
Birth Weight
Blood Glucose/an [Analysis]
Blood Pressure
Body Mass Index
Diabetes Mellitus, Type 1/bl [Blood]
Fasting
Feasibility Studies
Female
Fetal Macrosomia
Follow-Up Studies
Glucose Tolerance Test
Hemoglobin A, Glycosylated/an [Analysis]
Humans
Insulin/bl [Blood]
Male
Pilot Projects
Pregnancy
Pregnancy Trimesters
Prospective Studies
Young Adult
MedStar Health Research Institute
MedStar Washington Hospital Center
Obstetrics and Gynecology/Maternal-Fetal Medicine
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Available online through MWHC library: 2013 to the present
CONCLUSION: The hyperglycemic intrauterine environment is associated with short-term morbidity, manifested as asymmetric LGA (the "fat" baby). In addition, increasing level of maternal hyperglycemia during pregnancy is associated with increased adiposity and elevated fasting glucose in the young adult offspring. METHODS: We report findings from a feasibility study on 19 young adults, born to mothers with type 1 diabetes. Long-term follow-up of the offspring in young adulthood included: oral glucose tolerance test, body mass index (BMI), dual X-ray absorptiometry, and blood pressure (BP). We report z-BMI and z-BP to account for varying gender and age. OBJECTIVE: To test the hypothesis that fetal exposure to a hyperglycemic intrauterine environment in women with type 1 diabetes is associated with asymmetrically distributed excessive fetal growth and imprinting consistent with adverse health issues later in life. RESULTS: The young adults born to women with diabetes averaged 19.9 years at follow-up; 37% were female, and 21% African American. Maternal glycohemoglobin A(1) concentration in the 2nd trimester was 9.2% for offspring born with asymmetric LGA and 7.5% for those born with symmetric LGA or AGA. There was significant correlation between maternal glucose control during pregnancy and fasting glucose, z-BMI and z-systolic BP in the young adults.
English
1476-4954
*Diabetes Mellitus, Type 1/co [Complications]
*Pregnancy in Diabetics
*Prenatal Exposure Delayed Effects
Absorptiometry, Photon
Adiposity
Birth Weight
Blood Glucose/an [Analysis]
Blood Pressure
Body Mass Index
Diabetes Mellitus, Type 1/bl [Blood]
Fasting
Feasibility Studies
Female
Fetal Macrosomia
Follow-Up Studies
Glucose Tolerance Test
Hemoglobin A, Glycosylated/an [Analysis]
Humans
Insulin/bl [Blood]
Male
Pilot Projects
Pregnancy
Pregnancy Trimesters
Prospective Studies
Young Adult
MedStar Health Research Institute
MedStar Washington Hospital Center
Obstetrics and Gynecology/Maternal-Fetal Medicine
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural