Association of cord blood magnesium concentration and neonatal resuscitation.
Association of cord blood magnesium concentration and neonatal resuscitation.
Available online from MWHC library: 1995 - present
CONCLUSION: Cord blood Mg concentration does not correlate with the level of delivery room resuscitation of infants exposed to magnesium sulfate for fetal neuroprotection. Copyright A 2012 Mosby, Inc. All rights reserved. OBJECTIVE: To assess the relationship between umbilical cord blood magnesium concentration and level of delivery room resuscitation received by neonates. RESULTS: There was no relationship between cord blood Mg and delivery room resuscitation (OR, 0.92 for each 1.0-mEq/L increase in Mg; 95% CI, 0.83-1.03). Maternal general anesthesia was associated with increased neonatal resuscitation (OR, 2.51; 95% CI, 1.72-3.68). Each 1-week increase in gestational age at birth was associated with decreased neonatal resuscitation (OR, 0.63; 95% CI, 0.60-0.66). STUDY DESIGN: This was a secondary analysis of a controlled fetal neuroprotection trial that enrolled women at imminent risk for delivery between 24 and 31 weeks' gestation and randomly allocated them to receive either intravenous magnesium sulfate or placebo. The cohort included 1507 infants with data available on total cord blood Mg concentration and delivery room resuscitation. Multivariate logistic regression was used to estimate the association between cord blood Mg concentration and highest level of delivery room resuscitation, using the following hierarchy: none, oxygen only, bag-mask ventilation with oxygen, intubation, and chest compressions.
English
0022-3476
*Fetal Blood/ch [Chemistry]
*Magnesium Sulfate/bl [Blood]
*Resuscitation/sn [Statistics & Numerical Data]
Female
Humans
Infant, Newborn
Male
Prospective Studies
MedStar Health Research Institute
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Available online from MWHC library: 1995 - present
CONCLUSION: Cord blood Mg concentration does not correlate with the level of delivery room resuscitation of infants exposed to magnesium sulfate for fetal neuroprotection. Copyright A 2012 Mosby, Inc. All rights reserved. OBJECTIVE: To assess the relationship between umbilical cord blood magnesium concentration and level of delivery room resuscitation received by neonates. RESULTS: There was no relationship between cord blood Mg and delivery room resuscitation (OR, 0.92 for each 1.0-mEq/L increase in Mg; 95% CI, 0.83-1.03). Maternal general anesthesia was associated with increased neonatal resuscitation (OR, 2.51; 95% CI, 1.72-3.68). Each 1-week increase in gestational age at birth was associated with decreased neonatal resuscitation (OR, 0.63; 95% CI, 0.60-0.66). STUDY DESIGN: This was a secondary analysis of a controlled fetal neuroprotection trial that enrolled women at imminent risk for delivery between 24 and 31 weeks' gestation and randomly allocated them to receive either intravenous magnesium sulfate or placebo. The cohort included 1507 infants with data available on total cord blood Mg concentration and delivery room resuscitation. Multivariate logistic regression was used to estimate the association between cord blood Mg concentration and highest level of delivery room resuscitation, using the following hierarchy: none, oxygen only, bag-mask ventilation with oxygen, intubation, and chest compressions.
English
0022-3476
*Fetal Blood/ch [Chemistry]
*Magnesium Sulfate/bl [Blood]
*Resuscitation/sn [Statistics & Numerical Data]
Female
Humans
Infant, Newborn
Male
Prospective Studies
MedStar Health Research Institute
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural