Coronary microvascular dysfunction and inflammation: Insights from the Coronary Microvascular Disease Registry.
Coronary microvascular dysfunction and inflammation: Insights from the Coronary Microvascular Disease Registry.
- 2024
Available in print through MWHC library: 2002 - present
BACKGROUND: Coronary microvascular dysfunction (CMD) is associated with various inflammatory conditions that worsen endothelial dysfunction. This study aimed to investigate the relationship between CMD and inflammation using common inflammatory markers derived from complete blood count (CBC) analysis. CONCLUSION: Our findings did not show a noteworthy connection between CMD and inflammation, as suggested by various simple CBC-based biomarkers. Copyright © 2024. Published by Elsevier Inc. METHODS: Information was gathered from the Coronary Microvascular Disease Registry to examine the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-monocyte ratio (EMR), and monocyte-to-high-density lipoprotein ratio (MHR) in a cohort of patients with angina who showed non-obstructive coronary arteries and underwent invasive physiological assessments for CMD. RESULTS: Of the 171 patients studied, 126 were CMD-negative and 45 were CMD-positive, constituting two groups of interest. The average age of all patients was 61.7 +/- 11.1 years, and 63.7 % were female. No significant differences were observed between the two groups in terms of baseline characteristics, cardiovascular risk factors, or potential anti-inflammatory medications. Furthermore, there were no statistically significant differences in NLR (2.54 +/- 3.71 vs. 2.52 +/- 2.28, p = 0.97), EMR (0.3 +/- 0.21 vs. 0.34 +/- 0.29, p = 0.31), or MHR (0.02 +/- 0.01 vs. 0.01 +/- 0.01, p = 0.54) between CMD-positive and CMD-negative patients.
English
1878-0938
S1553-8389(24)00488-3 [pii]
IN PROCESS -- NOT YET INDEXED--Automated
MedStar Heart & Vascular Institute
MedStar Washington Hospital Center
Advanced Cardiac Catheterization Research Fellowship
Internal Medicine Residency
MedStar Georgetown University Hospital/MedStar Washington Hospital Center
Journal Article
Available in print through MWHC library: 2002 - present
BACKGROUND: Coronary microvascular dysfunction (CMD) is associated with various inflammatory conditions that worsen endothelial dysfunction. This study aimed to investigate the relationship between CMD and inflammation using common inflammatory markers derived from complete blood count (CBC) analysis. CONCLUSION: Our findings did not show a noteworthy connection between CMD and inflammation, as suggested by various simple CBC-based biomarkers. Copyright © 2024. Published by Elsevier Inc. METHODS: Information was gathered from the Coronary Microvascular Disease Registry to examine the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-monocyte ratio (EMR), and monocyte-to-high-density lipoprotein ratio (MHR) in a cohort of patients with angina who showed non-obstructive coronary arteries and underwent invasive physiological assessments for CMD. RESULTS: Of the 171 patients studied, 126 were CMD-negative and 45 were CMD-positive, constituting two groups of interest. The average age of all patients was 61.7 +/- 11.1 years, and 63.7 % were female. No significant differences were observed between the two groups in terms of baseline characteristics, cardiovascular risk factors, or potential anti-inflammatory medications. Furthermore, there were no statistically significant differences in NLR (2.54 +/- 3.71 vs. 2.52 +/- 2.28, p = 0.97), EMR (0.3 +/- 0.21 vs. 0.34 +/- 0.29, p = 0.31), or MHR (0.02 +/- 0.01 vs. 0.01 +/- 0.01, p = 0.54) between CMD-positive and CMD-negative patients.
English
1878-0938
S1553-8389(24)00488-3 [pii]
IN PROCESS -- NOT YET INDEXED--Automated
MedStar Heart & Vascular Institute
MedStar Washington Hospital Center
Advanced Cardiac Catheterization Research Fellowship
Internal Medicine Residency
MedStar Georgetown University Hospital/MedStar Washington Hospital Center
Journal Article