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Coronary microvascular dysfunction and inflammation: Insights from the Coronary Microvascular Disease Registry.

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Publication details: 2024; ; ISSN:

1878-0938

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Online resources:

https://dx.doi.org/10.1016/j.carrev.2024.05.020

Summary: BACKGROUND: Coronary microvascular dysfunction (CMD) is associated with various inflammatory conditions that worsen endothelial dysfunction. This study aimed to investigate the relationship between CMD and inflammation using common inflammatory markers derived from complete blood count (CBC) analysis.Summary: CONCLUSION: Our findings did not show a noteworthy connection between CMD and inflammation, as suggested by various simple CBC-based biomarkers. Copyright Â© 2024. Published by Elsevier Inc.Summary: METHODS: Information was gathered from the Coronary Microvascular Disease Registry to examine the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-monocyte ratio (EMR), and monocyte-to-high-density lipoprotein ratio (MHR) in a cohort of patients with angina who showed non-obstructive coronary arteries and underwent invasive physiological assessments for CMD.Summary: RESULTS: Of the 171 patients studied, 126 were CMD-negative and 45 were CMD-positive, constituting two groups of interest. The average age of all patients was 61.7 +/- 11.1 years, and 63.7 % were female. No significant differences were observed between the two groups in terms of baseline characteristics, cardiovascular risk factors, or potential anti-inflammatory medications. Furthermore, there were no statistically significant differences in NLR (2.54 +/- 3.71 vs. 2.52 +/- 2.28, p = 0.97), EMR (0.3 +/- 0.21 vs. 0.34 +/- 0.29, p = 0.31), or MHR (0.02 +/- 0.01 vs. 0.01 +/- 0.01, p = 0.54) between CMD-positive and CMD-negative patients.

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article		Available		38789342

Available in print through MWHC library: 2002 - present

BACKGROUND: Coronary microvascular dysfunction (CMD) is associated with various inflammatory conditions that worsen endothelial dysfunction. This study aimed to investigate the relationship between CMD and inflammation using common inflammatory markers derived from complete blood count (CBC) analysis.

METHODS: Information was gathered from the Coronary Microvascular Disease Registry to examine the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-monocyte ratio (EMR), and monocyte-to-high-density lipoprotein ratio (MHR) in a cohort of patients with angina who showed non-obstructive coronary arteries and underwent invasive physiological assessments for CMD.

RESULTS: Of the 171 patients studied, 126 were CMD-negative and 45 were CMD-positive, constituting two groups of interest. The average age of all patients was 61.7 +/- 11.1 years, and 63.7 % were female. No significant differences were observed between the two groups in terms of baseline characteristics, cardiovascular risk factors, or potential anti-inflammatory medications. Furthermore, there were no statistically significant differences in NLR (2.54 +/- 3.71 vs. 2.52 +/- 2.28, p = 0.97), EMR (0.3 +/- 0.21 vs. 0.34 +/- 0.29, p = 0.31), or MHR (0.02 +/- 0.01 vs. 0.01 +/- 0.01, p = 0.54) between CMD-positive and CMD-negative patients.

English