In vivo assessment of placental and brain volumes in growth-restricted fetuses with and without fetal Doppler changes using quantitative 3D MRI.
In vivo assessment of placental and brain volumes in growth-restricted fetuses with and without fetal Doppler changes using quantitative 3D MRI.
- 2017
CONCLUSION: Quantitative fetal MRI can accurately detect decreased placental and brain volumes in pregnancies with FGR and may provide insight into the timing and mechanisms of brain injury in FGR.Journal of Perinatology advance online publication, 24 August 2017; doi:10.1038/jp.2017.129. OBJECTIVE: The relationship between placental and fetal brain growth is poorly understood and difficult to assess. The objective of this study was to interrogate placental and fetal brain growth in healthy pregnancies and those complicated by fetal growth restriction (FGR). RESULTS: A total of 114 women (79 controls and 35 FGR) underwent MRI (median gestational age (GA) 30 weeks, range 18 to 39). All measured volumes increased exponentially with advancing GA. Placental, total brain, cerebral and cerebellar volumes were smaller in FGR compared with controls (P<0.05). Increasing placental volume was associated with increasing cerebral and cerebellar volumes (P<0.05). STUDY DESIGN: In a prospective, observational study, pregnant women with normal pregnancies or pregnancies complicated by FGR underwent fetal magnetic resonance imaging (MRI). Placental, global and regional brain volumes were calculated.
English
0743-8346
*Brain/dg [Diagnostic Imaging]
*Fetal Development
*Fetal Growth Retardation/dg [Diagnostic Imaging]
*Imaging, Three-Dimensional
*Magnetic Resonance Imaging/mt [Methods]
*Placenta/dg [Diagnostic Imaging]
Adolescent
Adult
Brain/pa [Pathology]
Case-Control Studies
Female
Gestational Age
Humans
Longitudinal Studies
Male
Organ Size
Placenta/pa [Pathology]
Predictive Value of Tests
Pregnancy
Prospective Studies
Ultrasonography, Prenatal
Young Adult
MedStar Washington Hospital Center
Obstetrics and Gynecology/Maternal-Fetal Medicine
Journal Article
CONCLUSION: Quantitative fetal MRI can accurately detect decreased placental and brain volumes in pregnancies with FGR and may provide insight into the timing and mechanisms of brain injury in FGR.Journal of Perinatology advance online publication, 24 August 2017; doi:10.1038/jp.2017.129. OBJECTIVE: The relationship between placental and fetal brain growth is poorly understood and difficult to assess. The objective of this study was to interrogate placental and fetal brain growth in healthy pregnancies and those complicated by fetal growth restriction (FGR). RESULTS: A total of 114 women (79 controls and 35 FGR) underwent MRI (median gestational age (GA) 30 weeks, range 18 to 39). All measured volumes increased exponentially with advancing GA. Placental, total brain, cerebral and cerebellar volumes were smaller in FGR compared with controls (P<0.05). Increasing placental volume was associated with increasing cerebral and cerebellar volumes (P<0.05). STUDY DESIGN: In a prospective, observational study, pregnant women with normal pregnancies or pregnancies complicated by FGR underwent fetal magnetic resonance imaging (MRI). Placental, global and regional brain volumes were calculated.
English
0743-8346
*Brain/dg [Diagnostic Imaging]
*Fetal Development
*Fetal Growth Retardation/dg [Diagnostic Imaging]
*Imaging, Three-Dimensional
*Magnetic Resonance Imaging/mt [Methods]
*Placenta/dg [Diagnostic Imaging]
Adolescent
Adult
Brain/pa [Pathology]
Case-Control Studies
Female
Gestational Age
Humans
Longitudinal Studies
Male
Organ Size
Placenta/pa [Pathology]
Predictive Value of Tests
Pregnancy
Prospective Studies
Ultrasonography, Prenatal
Young Adult
MedStar Washington Hospital Center
Obstetrics and Gynecology/Maternal-Fetal Medicine
Journal Article