Inhaled antibiotics for the treatment of pneumonia. [Review]
Inhaled antibiotics for the treatment of pneumonia. [Review]
- 2019
Available online from MWHC library: 1999 - present
PURPOSE OF REVIEW: To describe recent developments in trials exploring inhaled antibiotics for treating severe pneumonia. RECENT FINDINGS: Three recent randomized studies investigated the potential role for aerosolized antibiotics for gram-negative pneumonia in ventilated patients. One single center, nonblinded investigation suggested a benefit with inhaled amikacin for resistant gram-negative infections. However, two multicenter, blinded trials found no benefit to adjunctive nebulized amikacin for severe gram-negative pneumonia. SUMMARY: Well done clinical trials do not support the routine use of inhaled amikacin for pneumonia in ventilated patients. There may be a potential role for aerosolized antibiotics when other options are limited.
English
1070-5287
10.1097/MCP.0000000000000557 [doi]
*Amikacin/ad [Administration & Dosage]
*Anti-Bacterial Agents/ad [Administration & Dosage]
*Pneumonia, Bacterial/dt [Drug Therapy]
*Pneumonia, Ventilator-Associated/dt [Drug Therapy]
Administration, Inhalation
Humans
MedStar Washington Hospital Center
Medicine/Pulmonary-Critical Care
Journal Article
Available online from MWHC library: 1999 - present
PURPOSE OF REVIEW: To describe recent developments in trials exploring inhaled antibiotics for treating severe pneumonia. RECENT FINDINGS: Three recent randomized studies investigated the potential role for aerosolized antibiotics for gram-negative pneumonia in ventilated patients. One single center, nonblinded investigation suggested a benefit with inhaled amikacin for resistant gram-negative infections. However, two multicenter, blinded trials found no benefit to adjunctive nebulized amikacin for severe gram-negative pneumonia. SUMMARY: Well done clinical trials do not support the routine use of inhaled amikacin for pneumonia in ventilated patients. There may be a potential role for aerosolized antibiotics when other options are limited.
English
1070-5287
10.1097/MCP.0000000000000557 [doi]
*Amikacin/ad [Administration & Dosage]
*Anti-Bacterial Agents/ad [Administration & Dosage]
*Pneumonia, Bacterial/dt [Drug Therapy]
*Pneumonia, Ventilator-Associated/dt [Drug Therapy]
Administration, Inhalation
Humans
MedStar Washington Hospital Center
Medicine/Pulmonary-Critical Care
Journal Article