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Apical Resection and Cryoinjury of Neonatal Mouse Heart. - 2021

Neonatal mouse hearts have a regenerative capacity similar to adult zebrafish. Different cardiac injury models have been established to investigate the regenerative capacity of neonatal mouse hearts, including ventricular amputation, cryoinjury, and ligation of a major coronary artery. While the ventricular resection model can be utilized to study how tissue forms and regenerates de novo, cryoinjury and coronary artery ligation are methods that might better mimic myocardial infarction by creating tissue damage and necrosis as opposed to the removal of healthy tissue in the ventricular amputation model. Here we describe methods of creating ventricular resection and cardiac cryoinjury in newborn mice.


English

ISSN: 1064-3745

Standard No.: 10.1007/978-1-0716-0668-1_2 [doi]

Subjects--Topical Terms:
*Cardiac Surgical Procedures/ae [Adverse Effects]
*Cryosurgery/ae [Adverse Effects]
*Heart Injuries/pa [Pathology]
*Heart/ph [Physiology]
*Regeneration
*Ventricular Remodeling
Animals
Animals, Newborn
Cell Proliferation
Female
Heart Injuries/et [Etiology]
Heart Injuries/rh [Rehabilitation]
Male
Mice

Subjects--Geographic Terms:
MedStar Franklin Square Medical Center

Index Terms--Occupation:
Surgery

Index Terms--Function:
Journal Article