MARC details
| 000 -LEADER |
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| fixed length control field |
04536nam a22003977a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
220706s20222022 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2641-4368 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1162/nol_a_00069 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
nol_a_00069 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PMC9169899 [pmc] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
35686116 |
| 245 ## - TITLE STATEMENT |
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| Title |
A Weak Shadow of Early Life Language Processing Persists in the Right Hemisphere of the Mature Brain. |
| 251 ## - Source |
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| Source |
Neurobiology of Language. 3(3):364-385, 2022 May. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Neurobiol Lang (Camb). 3(3):364-385, 2022 May. |
| 253 ## - Journal Name |
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| Journal name |
Neurobiology of language (Cambridge, Mass.) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2022 May |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
epublish |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Medline status |
PubMed-not-MEDLINE |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2022-07-06 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Studies of language organization show a striking change in cerebral dominance for language over development: We begin life with a left hemisphere (LH) bias for language processing, which is weaker than that in adults and which can be overcome if there is a LH injury. Over development this LH bias becomes stronger and can no longer be reversed. Prior work has shown that this change results from a significant reduction in the magnitude of language activation in right hemisphere (RH) regions in adults compared to children. Here we investigate whether the spatial distribution of language activation, albeit weaker in magnitude, still persists in homotopic RH regions of the mature brain. Children aged 4-13 (n = 39) and young adults (n = 14) completed an auditory sentence comprehension fMRI (functional magnetic resonance imaging) task. To equate neural activity across the hemispheres, we applied fixed cutoffs for the number of active voxels that would be included in each hemisphere for each participant. To evaluate homotopicity, we generated left-right flipped versions of each activation map, calculated spatial overlap between the LH and RH activity in frontal and temporal regions, and tested for mean differences in the spatial overlap values between the age groups. We found that, in children as well as in adults, there was indeed a spatially intact shadow of language activity in the right frontal and temporal regions homotopic to the LH language regions. After a LH stroke in adulthood, recovering early-life activation in these regions might assist in enhancing recovery of language abilities. Copyright © 2022 Massachusetts Institute of Technology. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar National Rehabilitation Network |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Newport, Elissa L |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Seydell-Greenwald, Anna |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Turkeltaub, Peter E |
| 790 ## - Authors |
|---|
| All authors |
Berl MM, Gaillard WD, Martin KC, Newport EL, Seydell-Greenwald A, Turkeltaub PE |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="https://dx.doi.org/10.1162/nol_a_00069">https://dx.doi.org/10.1162/nol_a_00069</a> |
| Public note |
https://dx.doi.org/10.1162/nol_a_00069 |
| 858 ## - ORCID |
|---|
| ORCID text |
Newport, Elissa L |
| -- |
Seydell-Greenwald, Anna |
| -- |
Turkeltaub, Peter E |
| Orcid |
<a href="https://orcid.org/0000-0002-2783-5062">https://orcid.org/0000-0002-2783-5062</a> |
| -- |
<a href="https://orcid.org/0000-0002-7292-8575">https://orcid.org/0000-0002-7292-8575</a> |
| -- |
<a href="https://orcid.org/0000-0003-2080-6055">https://orcid.org/0000-0003-2080-6055</a> |
| Name |
https://orcid.org/0000-0002-2783-5062 |
| -- |
https://orcid.org/0000-0002-7292-8575 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0002-2783-5062 |
| -- |
https://orcid.org/0000-0002-7292-8575 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0002-2783-5062 |
| -- |
https://orcid.org/0000-0002-7292-8575 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| 858 ## - ORCID |
|---|
| ORCID text |
Newport, Elissa L |
| -- |
Seydell-Greenwald, Anna |
| -- |
Turkeltaub, Peter E |
| Orcid |
<a href="https://orcid.org/0000-0002-2783-5062">https://orcid.org/0000-0002-2783-5062</a> |
| -- |
<a href="https://orcid.org/0000-0002-7292-8575">https://orcid.org/0000-0002-7292-8575</a> |
| -- |
<a href="https://orcid.org/0000-0003-2080-6055">https://orcid.org/0000-0003-2080-6055</a> |
| Name |
https://orcid.org/0000-0002-2783-5062 |
| -- |
https://orcid.org/0000-0002-7292-8575 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0002-2783-5062 |
| -- |
https://orcid.org/0000-0002-7292-8575 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0002-2783-5062 |
| -- |
https://orcid.org/0000-0002-7292-8575 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| 858 ## - ORCID |
|---|
| ORCID text |
Newport, Elissa L |
| -- |
Seydell-Greenwald, Anna |
| -- |
Turkeltaub, Peter E |
| Orcid |
<a href="https://orcid.org/0000-0002-2783-5062">https://orcid.org/0000-0002-2783-5062</a> |
| -- |
<a href="https://orcid.org/0000-0002-7292-8575">https://orcid.org/0000-0002-7292-8575</a> |
| -- |
<a href="https://orcid.org/0000-0003-2080-6055">https://orcid.org/0000-0003-2080-6055</a> |
| Name |
https://orcid.org/0000-0002-2783-5062 |
| -- |
https://orcid.org/0000-0002-7292-8575 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0002-2783-5062 |
| -- |
https://orcid.org/0000-0002-7292-8575 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0002-2783-5062 |
| -- |
https://orcid.org/0000-0002-7292-8575 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
