MARC details
| 000 -LEADER |
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| fixed length control field |
03226nam a22003617a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180220s20182018 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1932-6203 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1371/journal.pone.0192769 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PONE-D-17-22004 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
29438431 |
| 245 ## - TITLE STATEMENT |
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| Title |
Novel animal model for Achilles tendinopathy: Controlled experimental study of serial injections of collagenase in rabbits. |
| 251 ## - Source |
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| Source |
PLoS ONE [Electronic Resource]. 13(2):e0192769, 2018 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
PLoS ONE. 13(2):e0192769, 2018 |
| 253 ## - Journal Name |
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| Journal name |
PloS one |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2018 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2018 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2018-02-20 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online through MWHC library: 2006 - present |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Our goal was to develop a novel technique for inducing Achilles tendinopathy in animal models which more accurately represents the progressive histological and biomechanical characteristic of chronic Achilles tendinopathy in humans. In this animal research study, forty-five rabbits were randomly assigned to three groups and given bilateral Achilles injections. Low dose (LD group) (n = 18) underwent a novel technique with three low-dose (0.1mg) injections of collagenase that were separated by two weeks, the high dose group (HD) (n = 18) underwent traditional single high-dose (0.3mg) injections, and the third group were controls (n = 9). Six rabbits were sacrificed from each experimental group (LD and HD) at 10, 12 and 16 weeks. Control animals were sacrificed after 16 weeks. Histological and biomechanical properties were then compared in all three groups. At 10 weeks, Bonar score and tendon cross sectional area was highest in HD group, with impaired biomechanical properties compared to LD group. At 12 weeks, Bonar score was higher in LD group, with similar biomechanical findings when compared to HD group. After 16 weeks, Bonar score was significantly increased for both LD group (11,8+/-2,28) and HD group (5,6+/-2,51), when compared to controls (2+/-0,76). LD group showed more pronounced histological and biomechanical findings, including cross sectional area of the tendon, Young's modulus, yield stress and ultimate tensile strength. In conclusion, Achilles tendinopathy in animal models that were induced by serial injections of low-dose collagenase showed more pronounced histological and biomechanical findings after 16 weeks than traditional techniques, mimicking better the progressive and chronic characteristic of the tendinopathy in humans. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Union Memorial Hospital |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Orthopaedic Surgery |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
da Fonseca, Lucas Furtado |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
de Cesar Netto, Cesar |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Schon, Lew C |
| 790 ## - Authors |
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| All authors |
Augusto Pontin P, Cavinatto LM, da Fonseca LF, de Camargo OP, de Cesar Netto C, Fernandes TD, Godoy-Santos AL, Lima FDO, Natalino RJM, Pereira CAM, Schon LC, Staggers JR |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1371/journal.pone.0192769">https://dx.doi.org/10.1371/journal.pone.0192769</a> |
| Public note |
https://dx.doi.org/10.1371/journal.pone.0192769 |
| 858 ## - ORCID |
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| ORCID text |
de Cesar Netto, Cesar |
| Orcid |
<a href="http://orcid.org/0000-0001-6037-0685">http://orcid.org/0000-0001-6037-0685</a> |
| Name |
http://orcid.org/0000-0001-6037-0685 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
