Comparison of outcome of higher versus lower transvalvular gradients in patients with severe aortic stenosis and low (<40%) left ventricular ejection fraction. (Record no. 1092)

MARC details
000 -LEADER
fixed length control field 04727nam a22007457a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130913s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0002-9149
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 22257710
245 ## - TITLE STATEMENT
Title Comparison of outcome of higher versus lower transvalvular gradients in patients with severe aortic stenosis and low (<40%) left ventricular ejection fraction.
251 ## - Source
Source American Journal of Cardiology. 109(7):1031-7, 2012 Apr 1.
252 ## - Abbreviated Source
Abbreviated source Am J Cardiol. 109(7):1031-7, 2012 Apr 1.
253 ## - Journal Name
Journal name The American journal of cardiology
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2012
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2012
266 ## - Date added to catalog
Date added to catalog 2013-09-17
501 ## - WITH NOTE
Local holdings Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
520 ## - SUMMARY, ETC.
Abstract Left ventricular systolic dysfunction in patients with severe aortic stenosis (AS) is associated with poor outcome. This analysis was designed primarily to describe the clinical course of a large series of consecutive patients with severe AS and low ejection fraction (EF) (<40%) who, because of high surgical risk, were referred for transcatheter aortic valve implantation consideration. A cohort of 270 patients with severe AS and low EF (<40%) who were referred to participate in a clinical trial of transcatheter aortic valve implantation was studied. Clinical, hemodynamic, and periprocedural complications and follow-up mortality data were collected and compared between patients with low mean transvalvular gradients (<=40 mm Hg, n = 170 [63%]) and high transvalvular gradients (>40 mm Hg, n = 100 [37%]). Patients with low gradients were younger (mean age 79.8 +/- 9.1 vs 83.8 +/- 7.7 years, p <0.001) and had higher incidences of coronary artery disease and renal failure. Mean aortic valve area was larger (0.73 +/- 0.23 vs 0.53 +/- 0.18 cm(2), p <0.001), while mean EF (26.4 +/- 6.9% vs 30.5% +/- 6.6%, p <0.001), cardiac output (3.7 +/- 1.1 vs 4.1 +/- 1.3 L/min, p = 0.04), and cardiac index (1.9 +/- 0.5 vs 2.1 +/- 0.6 L/min/m(2), p = 0.04) were lower in patients with lower gradients compared to those with higher gradients, respectively. Mortality was higher in patients with low gradients (53.8%) at a mean follow-up of 151 days compared to those with high gradients (41%) at a mean follow-up of 256 days (p = 0.01). In conclusion, patients with severe AS and low EF with low transvalvular gradients are at higher risk for worse outcomes compared to patients with high transvalvular gradients. Surgery or transcatheter aortic valve implantation treatment and high baseline transvalvular gradient are associated with EF improvement. Copyright A 2012. Published by Elsevier Inc.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Aortic Valve Stenosis/di [Diagnosis]
9 (RLIN) 901
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Aortic Valve Stenosis/su [Surgery]
9 (RLIN) 37
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Aortic Valve/su [Surgery]
9 (RLIN) 900
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Cardiac Catheterization
9 (RLIN) 32
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Heart Valve Prosthesis Implantation
9 (RLIN) 545
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Stroke Volume
9 (RLIN) 802
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged, 80 and over
9 (RLIN) 36
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged
9 (RLIN) 2
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Algorithms
9 (RLIN) 378
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve Stenosis/mo [Mortality]
9 (RLIN) 902
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve Stenosis/pp [Physiopathology]
9 (RLIN) 903
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve/pp [Physiopathology]
9 (RLIN) 899
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cardiac Catheterization/mt [Methods]
9 (RLIN) 540
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cohort Studies
9 (RLIN) 187
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
9 (RLIN) 7
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Follow-Up Studies
9 (RLIN) 904
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
9 (RLIN) 11
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Male
9 (RLIN) 14
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Prospective Studies
9 (RLIN) 177
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Risk Assessment
9 (RLIN) 514
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Risk Factors
9 (RLIN) 311
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Severity of Illness Index
9 (RLIN) 47
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Survival Analysis
9 (RLIN) 905
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Treatment Outcome
9 (RLIN) 18
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Heart & Vascular Institute
657 ## - INDEX TERM--FUNCTION
Medline publication type Comparative Study
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
657 ## - INDEX TERM--FUNCTION
Medline publication type Randomized Controlled Trial
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Ben-Dor, Itsik
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700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Goldstein, Steven A
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700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Hauville, Camille
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700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Iyasu, Getachew D
9 (RLIN) 896
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Laynez-Carnicero, Ana
9 (RLIN) 897
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Lindsay, Joseph
9 (RLIN) 137
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Maluenda, Gabriel
9 (RLIN) 286
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Okubagzi, Petros
9 (RLIN) 26
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Pichard, Augusto D
9 (RLIN) 27
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Satler, Lowell F
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700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Torguson, Rebecca
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700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Waksman, Ron
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700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Xue, Zhenyi
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790 ## - Authors
All authors Ben-Dor I, Goldstein SA, Hauville C, Iyasu GD, Laynez-Carnicero A, Lindsay J, Maluenda G, Okubagzi P, Pichard AD, Satler LF, Torguson R, Waksman R, Xue Z
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="http://dx.doi.org/10.1016/j.amjcard.2011.11.041">http://dx.doi.org/10.1016/j.amjcard.2011.11.041</a>
Public note http://dx.doi.org/10.1016/j.amjcard.2011.11.041
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Source of classification or shelving scheme Other/Generic Classification Scheme
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 09/17/2013   22257710 22257710 09/17/2013 09/17/2013 Journal Article

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