MARC details
| 000 -LEADER |
|---|
| fixed length control field |
11240nam a22006497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190724s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
0270-6474 |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1523/JNEUROSCI.2707-18.2019 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
JNEUROSCI.2707-18.2019 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
PMC6607747 [pmc] |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| PMID |
31061085 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Localization of Phonological and Semantic Contributions to Reading. |
| 251 ## - Source |
|---|
| Source |
Journal of Neuroscience. 39(27):5361-5368, 2019 07 03. |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
J Neurosci. 39(27):5361-5368, 2019 07 03. |
| 252 ## - Abbreviated Source |
|---|
| Former abbreviated source |
J Neurosci. 39(27):5361-5368, 2019 Jul 03. |
| 253 ## - Journal Name |
|---|
| Journal name |
The Journal of neuroscience : the official journal of the Society for Neuroscience |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Manufacturer |
FY2020 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
|---|
| Publication status |
ppublish |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2019-05-21 |
| 268 ## - Previous citation |
|---|
| -- |
Journal of Neuroscience. 39(27):5361-5368, 2019 Jul 03. |
| 501 ## - WITH NOTE |
|---|
| Local holdings |
Available online from MWHC library: 1981 - present (after 18 months) |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Copyright (c) 2019 the authors. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Reading involves the rapid extraction of sound and meaning from print through a cooperative division of labor between phonological and lexical-semantic processes. Whereas lesion studies of patients with stereotyped acquired reading deficits contributed to the notion of a dissociation between phonological and lexical-semantic reading, the neuroanatomical basis for effects of lexicality (word vs pseudoword), orthographic regularity (regular vs irregular spelling-sound correspondences), and concreteness (concrete vs abstract meaning) on reading is underspecified, particularly outside the context of strong behavioral dissociations. Support vector regression lesion-symptom mapping (LSM) of 73 left hemisphere stroke survivors (male and female human subjects) not preselected for stereotyped dissociations revealed the differential contributions of specific cortical regions to reading pseudowords (ventral precentral gyrus), regular words (planum temporale, supramarginal gyrus, ventral precentral and postcentral gyrus, and insula), and concrete words (pars orbitalis and pars triangularis). Consistent with the primary systems view of reading being parasitic on language-general circuitry, our multivariate LSM analyses revealed that phonological decoding depends on perisylvian areas subserving sound-motor integration and that semantic effects on reading depend on frontal cortex subserving control over concrete semantic representations that aid phonological access from print. As the first study to localize the differential cortical contributions to reading pseudowords, regular words, and concrete words in stroke survivors with variable reading abilities, our results provide important information on the neurobiological basis of reading and highlight the insights attainable through multivariate, process-based approaches to alexia.<b>SIGNIFICANCE STATEMENT</b> Whereas fMRI evidence for neuroanatomical dissociations between phonological and lexical-semantic reading is abundant, evidence from modern lesion studies establishing the differential contributions of specific brain regions to specific reading processes is lacking. Our application of multivariate lesion-symptom mapping revealed that effects of lexicality, orthographic regularity, and concreteness on reading differentially depend on areas subserving auditory-motor integration and semantic control. Phonological decoding of print relies on a dorsal perisylvian network supporting auditory and articulatory representations, with unfamiliar words relying especially on articulatory mapping. In tandem with this dorsal decoding system, anterior inferior frontal gyrus may coordinate control over concrete semantic representations that support mapping of print to sound, which is a novel potential mechanism for semantic influences on reading. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Brain/ph [Physiology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Linguistics |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Reading |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Semantics |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Adult |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Brain/pa [Pathology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Female |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Magnetic Resonance Imaging |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Male |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Middle Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Stroke/pa [Pathology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Stroke/px [Psychology] |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar National Rehabilitation Network |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Neurology |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Dickens, J Vivian |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Fama, Mackenzie E |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Friedman, Rhonda B |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Lacey, Elizabeth H |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Turkeltaub, Peter E |
| 790 ## - Authors |
|---|
| All authors |
DeMarco AT, Dickens JV, Fama ME, Friedman RB, Lacey EH, Turkeltaub PE |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="https://dx.doi.org/10.1523/JNEUROSCI.2707-18.2019">https://dx.doi.org/10.1523/JNEUROSCI.2707-18.2019</a> |
| Public note |
https://dx.doi.org/10.1523/JNEUROSCI.2707-18.2019 |
| 858 ## - ORCID |
|---|
| ORCID text |
Dickens, J Vivian |
| -- |
Fama, Mackenzie E |
| -- |
Friedman, Rhonda B |
| -- |
Lacey, Elizabeth H |
| -- |
Turkeltaub, Peter E |
| Orcid |
<a href="https://orcid.org/0000-0001-8874-5442">https://orcid.org/0000-0001-8874-5442</a> |
| -- |
<a href="https://orcid.org/0000-0001-8549-7623">https://orcid.org/0000-0001-8549-7623</a> |
| -- |
<a href="https://orcid.org/0000-0001-6366-5251">https://orcid.org/0000-0001-6366-5251</a> |
| -- |
<a href="https://orcid.org/0000-0002-9389-0211">https://orcid.org/0000-0002-9389-0211</a> |
| -- |
<a href="https://orcid.org/0000-0003-2080-6055">https://orcid.org/0000-0003-2080-6055</a> |
| Name |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| 858 ## - ORCID |
|---|
| ORCID text |
Dickens, J Vivian |
| -- |
Fama, Mackenzie E |
| -- |
Friedman, Rhonda B |
| -- |
Lacey, Elizabeth H |
| -- |
Turkeltaub, Peter E |
| Orcid |
<a href="https://orcid.org/0000-0001-8874-5442">https://orcid.org/0000-0001-8874-5442</a> |
| -- |
<a href="https://orcid.org/0000-0001-8549-7623">https://orcid.org/0000-0001-8549-7623</a> |
| -- |
<a href="https://orcid.org/0000-0001-6366-5251">https://orcid.org/0000-0001-6366-5251</a> |
| -- |
<a href="https://orcid.org/0000-0002-9389-0211">https://orcid.org/0000-0002-9389-0211</a> |
| -- |
<a href="https://orcid.org/0000-0003-2080-6055">https://orcid.org/0000-0003-2080-6055</a> |
| Name |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| 858 ## - ORCID |
|---|
| ORCID text |
Dickens, J Vivian |
| -- |
Fama, Mackenzie E |
| -- |
Friedman, Rhonda B |
| -- |
Lacey, Elizabeth H |
| -- |
Turkeltaub, Peter E |
| Orcid |
<a href="https://orcid.org/0000-0001-8874-5442">https://orcid.org/0000-0001-8874-5442</a> |
| -- |
<a href="https://orcid.org/0000-0001-8549-7623">https://orcid.org/0000-0001-8549-7623</a> |
| -- |
<a href="https://orcid.org/0000-0001-6366-5251">https://orcid.org/0000-0001-6366-5251</a> |
| -- |
<a href="https://orcid.org/0000-0002-9389-0211">https://orcid.org/0000-0002-9389-0211</a> |
| -- |
<a href="https://orcid.org/0000-0003-2080-6055">https://orcid.org/0000-0003-2080-6055</a> |
| Name |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| 858 ## - ORCID |
|---|
| ORCID text |
Dickens, J Vivian |
| -- |
Fama, Mackenzie E |
| -- |
Friedman, Rhonda B |
| -- |
Lacey, Elizabeth H |
| -- |
Turkeltaub, Peter E |
| Orcid |
<a href="https://orcid.org/0000-0001-8874-5442">https://orcid.org/0000-0001-8874-5442</a> |
| -- |
<a href="https://orcid.org/0000-0001-8549-7623">https://orcid.org/0000-0001-8549-7623</a> |
| -- |
<a href="https://orcid.org/0000-0001-6366-5251">https://orcid.org/0000-0001-6366-5251</a> |
| -- |
<a href="https://orcid.org/0000-0002-9389-0211">https://orcid.org/0000-0002-9389-0211</a> |
| -- |
<a href="https://orcid.org/0000-0003-2080-6055">https://orcid.org/0000-0003-2080-6055</a> |
| Name |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| 858 ## - ORCID |
|---|
| ORCID text |
Dickens, J Vivian |
| -- |
Fama, Mackenzie E |
| -- |
Friedman, Rhonda B |
| -- |
Lacey, Elizabeth H |
| -- |
Turkeltaub, Peter E |
| Orcid |
<a href="https://orcid.org/0000-0001-8874-5442">https://orcid.org/0000-0001-8874-5442</a> |
| -- |
<a href="https://orcid.org/0000-0001-8549-7623">https://orcid.org/0000-0001-8549-7623</a> |
| -- |
<a href="https://orcid.org/0000-0001-6366-5251">https://orcid.org/0000-0001-6366-5251</a> |
| -- |
<a href="https://orcid.org/0000-0002-9389-0211">https://orcid.org/0000-0002-9389-0211</a> |
| -- |
<a href="https://orcid.org/0000-0003-2080-6055">https://orcid.org/0000-0003-2080-6055</a> |
| Name |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| -- |
https://orcid.org/0000-0001-8874-5442 |
| -- |
https://orcid.org/0000-0001-8549-7623 |
| -- |
https://orcid.org/0000-0001-6366-5251 |
| -- |
https://orcid.org/0000-0002-9389-0211 |
| -- |
https://orcid.org/0000-0003-2080-6055 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
