MARC details
000 -LEADER |
fixed length control field |
05328nam a22006017a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
221027s20222022 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
0027-8424 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1073/pnas.2207293119 [doi] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
36215488 |
245 ## - TITLE STATEMENT |
Title |
Language and developmental plasticity after perinatal stroke. |
251 ## - Source |
Source |
Proceedings of the National Academy of Sciences of the United States of America. 119(42):e2207293119, 2022 Oct 18. |
252 ## - Abbreviated Source |
Abbreviated source |
Proc Natl Acad Sci U S A. 119(42):e2207293119, 2022 Oct 18. |
253 ## - Journal Name |
Journal name |
Proceedings of the National Academy of Sciences of the United States of America |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2022 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2023 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Publication date |
2022 Oct 18 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
ppublish |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Medline status |
MEDLINE |
266 ## - Date added to catalog |
Date added to catalog |
2022-10-27 |
520 ## - SUMMARY, ETC. |
Abstract |
The mature human brain is lateralized for language, with the left hemisphere (LH) primarily responsible for sentence processing and the right hemisphere (RH) primarily responsible for processing suprasegmental aspects of language such as vocal emotion. However, it has long been hypothesized that in early life there is plasticity for language, allowing young children to acquire language in other cortical regions when LH areas are damaged. If true, what are the constraints on functional reorganization? Which areas of the brain can acquire language, and what happens to the functions these regions ordinarily perform? We address these questions by examining long-term outcomes in adolescents and young adults who, as infants, had a perinatal arterial ischemic stroke to the LH areas ordinarily subserving sentence processing. We compared them with their healthy age-matched siblings. All participants were tested on a battery of behavioral and functional imaging tasks. While stroke participants were impaired in some nonlinguistic cognitive abilities, their processing of sentences and of vocal emotion was normal and equal to that of their healthy siblings. In almost all, these abilities have both developed in the healthy RH. Our results provide insights into the remarkable ability of the young brain to reorganize language. Reorganization is highly constrained, with sentence processing almost always in the RH frontotemporal regions homotopic to their location in the healthy brain. This activation is somewhat segregated from RH emotion processing, suggesting that the two functions perform best when each has its own neural territory. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Language |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Stroke |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Adolescent |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Brain Mapping/mt [Methods] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Brain/ph [Physiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Child |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Child, Preschool |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Functional Laterality/ph [Physiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Magnetic Resonance Imaging/mt [Methods] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Neuronal Plasticity/ph [Physiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Young Adult |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar National Rehabilitation Network |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Chambers, Catherine E |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Dromerick, Alexander W |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Gaillard, William D |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Giannetti, Margot |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Landau, Barbara |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Martin, Kelly C |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Newport, Elissa L |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Rennert, Rebecca |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Seydell-Greenwald, Anna |
Institution Code |
MNRN |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Turkeltaub, Peter E |
Institution Code |
MNRN |
790 ## - Authors |
All authors |
Berl MM, Carpenter JL, Chambers CE, Dromerick AW, Gaillard WD, Giannetti M, Ichord RN, Landau B, Martin KC, Newport EL, Rennert R, Seydell-Greenwald A, Turkeltaub PE |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1073/pnas.2207293119">https://dx.doi.org/10.1073/pnas.2207293119</a> |
Public note |
https://dx.doi.org/10.1073/pnas.2207293119 |
858 ## - ORCID |
ORCID text |
Berl, Madison M |
-- |
Newport, Elissa L |
-- |
Seydell-Greenwald, Anna |
Orcid |
<a href="https://orcid.org/0000-0002-2469-1518">https://orcid.org/0000-0002-2469-1518</a> |
-- |
<a href="https://orcid.org/0000-0002-2783-5062">https://orcid.org/0000-0002-2783-5062</a> |
-- |
<a href="https://orcid.org/0000-0002-7292-8575">https://orcid.org/0000-0002-7292-8575</a> |
Name |
https://orcid.org/0000-0002-2469-1518 |
-- |
https://orcid.org/0000-0002-2783-5062 |
-- |
https://orcid.org/0000-0002-7292-8575 |
-- |
https://orcid.org/0000-0002-2469-1518 |
-- |
https://orcid.org/0000-0002-2783-5062 |
-- |
https://orcid.org/0000-0002-7292-8575 |
-- |
https://orcid.org/0000-0002-2469-1518 |
-- |
https://orcid.org/0000-0002-2783-5062 |
-- |
https://orcid.org/0000-0002-7292-8575 |
858 ## - ORCID |
ORCID text |
Berl, Madison M |
-- |
Newport, Elissa L |
-- |
Seydell-Greenwald, Anna |
Orcid |
<a href="https://orcid.org/0000-0002-2469-1518">https://orcid.org/0000-0002-2469-1518</a> |
-- |
<a href="https://orcid.org/0000-0002-2783-5062">https://orcid.org/0000-0002-2783-5062</a> |
-- |
<a href="https://orcid.org/0000-0002-7292-8575">https://orcid.org/0000-0002-7292-8575</a> |
Name |
https://orcid.org/0000-0002-2469-1518 |
-- |
https://orcid.org/0000-0002-2783-5062 |
-- |
https://orcid.org/0000-0002-7292-8575 |
-- |
https://orcid.org/0000-0002-2469-1518 |
-- |
https://orcid.org/0000-0002-2783-5062 |
-- |
https://orcid.org/0000-0002-7292-8575 |
-- |
https://orcid.org/0000-0002-2469-1518 |
-- |
https://orcid.org/0000-0002-2783-5062 |
-- |
https://orcid.org/0000-0002-7292-8575 |
858 ## - ORCID |
ORCID text |
Berl, Madison M |
-- |
Newport, Elissa L |
-- |
Seydell-Greenwald, Anna |
Orcid |
<a href="https://orcid.org/0000-0002-2469-1518">https://orcid.org/0000-0002-2469-1518</a> |
-- |
<a href="https://orcid.org/0000-0002-2783-5062">https://orcid.org/0000-0002-2783-5062</a> |
-- |
<a href="https://orcid.org/0000-0002-7292-8575">https://orcid.org/0000-0002-7292-8575</a> |
Name |
https://orcid.org/0000-0002-2469-1518 |
-- |
https://orcid.org/0000-0002-2783-5062 |
-- |
https://orcid.org/0000-0002-7292-8575 |
-- |
https://orcid.org/0000-0002-2469-1518 |
-- |
https://orcid.org/0000-0002-2783-5062 |
-- |
https://orcid.org/0000-0002-7292-8575 |
-- |
https://orcid.org/0000-0002-2469-1518 |
-- |
https://orcid.org/0000-0002-2783-5062 |
-- |
https://orcid.org/0000-0002-7292-8575 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |