MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02980nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
201229s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
2050-3121 |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| PMID |
33014372 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Virologic suppression in patients with a documented M184V/I mutation based on the number of active agents in the antiretroviral regimen. |
| 251 ## - Source |
|---|
| Source |
SAGE Open Medicine. 8:2050312120960570, 2020. |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
SAGE Open Med. 8:2050312120960570, 2020. |
| 253 ## - Journal Name |
|---|
| Journal name |
SAGE open medicine |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Year |
2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Manufacturer |
FY2021 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
|---|
| Publication status |
epublish |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2020-12-29 |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Conclusion: Similar rates of viral suppression were observed in patients regardless of the number of active antiretroviral agents prescribed. Regimens containing less than 3 active agents may maintain virologic suppression in patients with the M184V/I mutation. Further studies are needed to determine optimal antiretroviral therapy for patients with the M184V/I mutation. Copyright (c) The Author(s) 2020. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Methods: A retrospective chart review was conducted of 100 treatment-experienced patients harboring the M184V/I mutation seen at an urban HIV clinic. Efficacy was classified as percentage of patients with viral suppression defined as HIV RNA viral load <200 copies/mL at last measurement on current antiretroviral therapy, stratified by the number of active antiretroviral agents. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Objectives: The optimal antiretroviral therapy for patients with the M184V/I mutation is not known. The primary objective of this study was to determine the efficacy of various antiretroviral therapies in patients with HIV and the M184V/I mutation based on the number of active antiretroviral agents. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Results: The primary outcome of viral suppression occurred in 70.6% (12/17) of patients on <2 active agents, 77.2% (44/57) on 2-2.5 active agents, and 69.2% (18/26) on 3 active agents. No significant difference was found between viral suppression and patients on <2 and 2-2.5 antiretroviral agents (odds ratio = 0.71, 95% confidence interval = (0.21, 2.39), p = 0.8) or between patients on 3 and 2-2.5 active agents (odds ratio = 0.66, 95% confidence interval = (0.23, 1.88), p = 0.7). The most commonly prescribed regimen consisted of a boosted protease inhibitor with an integrase strand transfer inhibitor and two nucleoside reverse transcriptase inhibitors, one of which being lamivudine or emtricitabine. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar Union Memorial Hospital |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Pharmacy |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Mouradjian, Mallory T |
| 790 ## - Authors |
|---|
| All authors |
Heil EL, Mouradjian MT, Pandit NS, Sueng H |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="https://dx.doi.org/10.1177/2050312120960570">https://dx.doi.org/10.1177/2050312120960570</a> |
| Public note |
https://dx.doi.org/10.1177/2050312120960570 |
| 858 ## - ORCID |
|---|
| ORCID text |
Mouradjian, Mallory T |
| Orcid |
<a href="https://orcid.org/0000-0002-1870-0692">https://orcid.org/0000-0002-1870-0692</a> |
| Name |
https://orcid.org/0000-0002-1870-0692 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
