Risk factors for bleeding hepatocellular adenoma in a United States cohort. (Record no. 11060)
[ view plain ]
000 -LEADER | |
---|---|
fixed length control field | 03920nam a22005657a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 220516s20222022 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
International Standard Serial Number | 1478-3223 |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1111/liv.15087 [doi] |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
PMID | 34687281 |
245 ## - TITLE STATEMENT | |
Title | Risk factors for bleeding hepatocellular adenoma in a United States cohort. |
251 ## - Source | |
Source | Liver International. 42(1):224-232, 2022 01. |
252 ## - Abbreviated Source | |
Abbreviated source | Liver Int. 42(1):224-232, 2022 01. |
253 ## - Journal Name | |
Journal name | Liver international : official journal of the International Association for the Study of the Liver |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Year | 2022 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Manufacturer | FY2022 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Publication date | 2022 01 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
Publication status | ppublish |
520 ## - SUMMARY, ETC. | |
Abstract | BACKGROUND & AIMS: Known risk factors for hepatocellular adenoma (HCA) bleeding are size >5 cm, growth rate, visible vascularity, exophytic lesions, beta-catenin and Sonic Hedgehog activated HCAs. Most studies are based on European cohorts. The objective of this study is to identify additional risk factors for HCA bleeding in a US cohort. |
520 ## - SUMMARY, ETC. | |
Abstract | CONCLUSIONS: In a large US cohort, size predicted increased risk of HCA bleeding while hepatic adenomatosis trended towards increased risk of bleeding. In patients with multiple HCAs, size predicted bleeding and hepatic steatosis trended toward increased risk of bleeding. Copyright ♭ 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
520 ## - SUMMARY, ETC. | |
Abstract | METHODS: Retrospective chart review was performed on patients diagnosed with HCA on magnetic resonance imaging (n = 184) at an academic tertiary institution. Clinical, pathological, and imaging data were collected. Primary outcomes measured were HCA bleeding and malignancy. Statistical analysis was performed with SAS 9.4 using Chi-Square, Fisher's exact test, sample t test, non-parametric Wilcoxon test, and logistic regression. |
520 ## - SUMMARY, ETC. | |
Abstract | RESULTS: After excluding patients whose pathology showed focal nodular hyperplasia and non-adenoma lesions, follow-up data were available for 167 patients. 16% experienced microscopic or macroscopic bleeding and 1.2% had malignancy. HCA size predicted bleeding (P < .0001) and no patients with lesion size <1.8 cm bled. In unadjusted analysis, hepatic adenomatosis (>=10 lesions) trended towards 2.8-fold increased risk of bleeding. Of patients with a single lesion that bled, 77% bled from a lesion >5 cm. In patients with multiple HCAs that bled, 50% bled from lesions <5 cm. In patients with multiple adenomas, size (P = .001) independently predicted bleeding and hepatic steatosis trended towards increased risk of bleeding (P = .05). |
546 ## - LANGUAGE NOTE | |
Language note | English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Adenoma, Liver Cell |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Carcinoma, Hepatocellular |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Liver Neoplasms |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Adenoma, Liver Cell/co [Complications] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Adenoma, Liver Cell/di [Diagnosis] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Adenoma, Liver Cell/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Carcinoma, Hepatocellular/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Carcinoma, Hepatocellular/pa [Pathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Hedgehog Proteins |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Liver Neoplasms/pa [Pathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Magnetic Resonance Imaging |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Retrospective Studies |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Risk Factors |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | United States/ep [Epidemiology] |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
Institution | MedStar Health Research Institute |
656 ## - INDEX TERM--OCCUPATION | |
Department | MedStar General Surgery Residency |
656 ## - INDEX TERM--OCCUPATION | |
Department | MedStar Georgetown University Hospital/MedStar Washington Hospital Center |
657 ## - INDEX TERM--FUNCTION | |
Medline publication type | Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Desale, Sameer |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Fernandez, Stephen |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | McDermott, Chelsea |
790 ## - Authors | |
All authors | Desale S, Ertreo M, Fernandez S, Fishbein T, Hsu CC, Jha R, Ko J, McDermott C, Satoskar R, Smith C, Winslow E |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
DOI | <a href="https://dx.doi.org/10.1111/liv.15087">https://dx.doi.org/10.1111/liv.15087</a> |
Public note | https://dx.doi.org/10.1111/liv.15087 |
858 ## - ORCID | |
ORCID text | McDermott, Chelsea |
Orcid | <a href="https://orcid.org/0000-0001-7464-7550">https://orcid.org/0000-0001-7464-7550</a> |
Name | https://orcid.org/0000-0001-7464-7550 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Koha item type | Journal Article |
No items available.