Risk factors for bleeding hepatocellular adenoma in a United States cohort. (Record no. 11060)

MARC details
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fixed length control field 03920nam a22005657a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 220516s20222022 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1478-3223
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1111/liv.15087 [doi]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 34687281
245 ## - TITLE STATEMENT
Title Risk factors for bleeding hepatocellular adenoma in a United States cohort.
251 ## - Source
Source Liver International. 42(1):224-232, 2022 01.
252 ## - Abbreviated Source
Abbreviated source Liver Int. 42(1):224-232, 2022 01.
253 ## - Journal Name
Journal name Liver international : official journal of the International Association for the Study of the Liver
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2022
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Manufacturer FY2022
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Publication date 2022 01
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status ppublish
520 ## - SUMMARY, ETC.
Abstract BACKGROUND & AIMS: Known risk factors for hepatocellular adenoma (HCA) bleeding are size >5 cm, growth rate, visible vascularity, exophytic lesions, beta-catenin and Sonic Hedgehog activated HCAs. Most studies are based on European cohorts. The objective of this study is to identify additional risk factors for HCA bleeding in a US cohort.
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Abstract CONCLUSIONS: In a large US cohort, size predicted increased risk of HCA bleeding while hepatic adenomatosis trended towards increased risk of bleeding. In patients with multiple HCAs, size predicted bleeding and hepatic steatosis trended toward increased risk of bleeding. Copyright ♭ 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Abstract METHODS: Retrospective chart review was performed on patients diagnosed with HCA on magnetic resonance imaging (n = 184) at an academic tertiary institution. Clinical, pathological, and imaging data were collected. Primary outcomes measured were HCA bleeding and malignancy. Statistical analysis was performed with SAS 9.4 using Chi-Square, Fisher's exact test, sample t test, non-parametric Wilcoxon test, and logistic regression.
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Abstract RESULTS: After excluding patients whose pathology showed focal nodular hyperplasia and non-adenoma lesions, follow-up data were available for 167 patients. 16% experienced microscopic or macroscopic bleeding and 1.2% had malignancy. HCA size predicted bleeding (P < .0001) and no patients with lesion size <1.8 cm bled. In unadjusted analysis, hepatic adenomatosis (>=10 lesions) trended towards 2.8-fold increased risk of bleeding. Of patients with a single lesion that bled, 77% bled from a lesion >5 cm. In patients with multiple HCAs that bled, 50% bled from lesions <5 cm. In patients with multiple adenomas, size (P = .001) independently predicted bleeding and hepatic steatosis trended towards increased risk of bleeding (P = .05).
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Adenoma, Liver Cell
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Topical term or geographic name entry element *Carcinoma, Hepatocellular
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Topical term or geographic name entry element *Liver Neoplasms
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Topical term or geographic name entry element Adenoma, Liver Cell/co [Complications]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Adenoma, Liver Cell/di [Diagnosis]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Adenoma, Liver Cell/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Carcinoma, Hepatocellular/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Carcinoma, Hepatocellular/pa [Pathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hedgehog Proteins
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Topical term or geographic name entry element Humans
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Topical term or geographic name entry element Liver Neoplasms/pa [Pathology]
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Topical term or geographic name entry element Magnetic Resonance Imaging
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Topical term or geographic name entry element Retrospective Studies
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Topical term or geographic name entry element Risk Factors
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Topical term or geographic name entry element United States/ep [Epidemiology]
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute
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Department MedStar General Surgery Residency
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Department MedStar Georgetown University Hospital/MedStar Washington Hospital Center
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Medline publication type Journal Article
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Local Authors Desale, Sameer
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Local Authors Fernandez, Stephen
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Local Authors McDermott, Chelsea
790 ## - Authors
All authors Desale S, Ertreo M, Fernandez S, Fishbein T, Hsu CC, Jha R, Ko J, McDermott C, Satoskar R, Smith C, Winslow E
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1111/liv.15087">https://dx.doi.org/10.1111/liv.15087</a>
Public note https://dx.doi.org/10.1111/liv.15087
858 ## - ORCID
ORCID text McDermott, Chelsea
Orcid <a href="https://orcid.org/0000-0001-7464-7550">https://orcid.org/0000-0001-7464-7550</a>
Name https://orcid.org/0000-0001-7464-7550
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article

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