MARC details
| 000 -LEADER |
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| fixed length control field |
04373nam a22005777a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
220221s20222022 xxu||||| |||| 00| 0 eng d |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1177/02676591211057506 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
35000466 |
| 245 ## - TITLE STATEMENT |
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| Title |
The Interplay of Inflammation and Coagulation in COVID-19 Patients Receiving Extracorporeal Membrane Oxygenation Support. |
| 251 ## - Source |
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| Source |
Perfusion. :2676591211057506, 2022 Jan 09 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Perfusion. :2676591211057506, 2022 Jan 09 |
| 253 ## - Journal Name |
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| Journal name |
Perfusion |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2022 Jan 09 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2022-02-21 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSION: The correlation between inflammation and coagulation in the nonsurvivors supported with VV ECMO could indicate dysregulated inflammatory response and worse clinical outcomes. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
INTERVENTION: None. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
MEASUREMENTS AND MAIN RESULTS: Thirty-two patients were supported with VV ECMO during the study period, and 17 patients (53%) survived to hospital discharge. The ECMO nonsurvivors mean lactate dehydrogenase (LDH) levels were markedly elevated in comparison to survivors (1046 u/L [IQR = 509, 1305] vs 489 u/L [385 658], p = 0.003). Platelet/fibrinogen dysfunction, as reflected by the low Maximum Amplitude (MA) on viscoelastic testing, was worse in nonsurvivors (65.25 mm [60.68, 67.67] vs 74.80 mm [73.10, 78.40], p = 0.01). Time-group interaction for the first seven days of ECMO support, showed significantly lower platelet count in the nonsurvivors (140 k/ul [103, 170] vs 189.5 k/ul [ 146, 315], p < 0.001) and higher D-dimer in (21 mug/mL [13, 21] vs 14 mug/mL [3, 21], p < 0.001) in comparison to the survivors. Finally, we found profound statistically significant correlations between the clinical markers of inflammation and markers of coagulation in the nonsurvivors group. The ECMO nonsurvivors experienced higher rate of bleeding (73.3% vs 35.3%, p = 0.03), digital ischemia (46.7% vs 11.8%, p = 0.02), acute renal failure (60% vs 11.8%, p = 0.01) and bloodstream infection (60% vs 23.5%, p = 0.03). |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
OBJECTIVE: Bleeding and thrombosis are common complications during Extracorporeal Membrane Oxygenation (ECMO) support for COVID-19 patients. We sought to examine the relationship between inflammatory status, coagulation effects, and observed bleeding and thrombosis in patients receiving venovenous (VV) ECMO for COVID-19 respiratory failure. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
PATIENTS: The study period from April 1, 2020, to January 1, 2021, we included all patients with confirmed COVID-19 who received VV ECMO support. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
SETTINGS: Quaternary care institution. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
STUDY DESIGN: Cross-sectional cohort study. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Heart & Vascular Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Heart & Vascular Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Firefighters' Burn and Surgical Research Laboratory |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Internal Medicine Residency |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Medicine/Internal Medicine |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Medicine/Pulmonary-Critical Care |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Alnababteh, Muhtadi |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Desale, Sameer |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Kitahara, Hiroto |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Kriner, Eric |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Molina, Ezequiel |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Sallam, Tariq |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Shupp, Jeffrey W |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Varghese, Jobin |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Zaaqoq, Akram |
| 790 ## - Authors |
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| All authors |
Alnababteh M, Dalton H, Desale S, Galloway LA, Kitahara H, Kriner E, Merley C, Molina E, Sallam T, Shupp J, Varghese J, Zaaqoq A |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1177/02676591211057506">https://dx.doi.org/10.1177/02676591211057506</a> |
| Public note |
https://dx.doi.org/10.1177/02676591211057506 |
| 858 ## - ORCID |
|---|
| ORCID text |
Alnababteh, Muhtadi |
| -- |
Zaaqoq, Akram |
| Orcid |
<a href="https://orcid.org/0000-0001-8521-9260">https://orcid.org/0000-0001-8521-9260</a> |
| -- |
<a href="https://orcid.org/0000-0003-3147-5044">https://orcid.org/0000-0003-3147-5044</a> |
| Name |
https://orcid.org/0000-0001-8521-9260 |
| -- |
https://orcid.org/0000-0003-3147-5044 |
| -- |
https://orcid.org/0000-0001-8521-9260 |
| -- |
https://orcid.org/0000-0003-3147-5044 |
| 858 ## - ORCID |
|---|
| ORCID text |
Alnababteh, Muhtadi |
| -- |
Zaaqoq, Akram |
| Orcid |
<a href="https://orcid.org/0000-0001-8521-9260">https://orcid.org/0000-0001-8521-9260</a> |
| -- |
<a href="https://orcid.org/0000-0003-3147-5044">https://orcid.org/0000-0003-3147-5044</a> |
| Name |
https://orcid.org/0000-0001-8521-9260 |
| -- |
https://orcid.org/0000-0003-3147-5044 |
| -- |
https://orcid.org/0000-0001-8521-9260 |
| -- |
https://orcid.org/0000-0003-3147-5044 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
