Bacitracin for Injection Recall: Impact on Immediate Breast Implant Surgical Outcomes. (Record no. 11157)

MARC details
000 -LEADER
fixed length control field 05578nam a22006017a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 221018s20222022 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1075-122X
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1155/2022/1389539 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code PMC9453011 [pmc]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 36105366
245 ## - TITLE STATEMENT
Title Bacitracin for Injection Recall: Impact on Immediate Breast Implant Surgical Outcomes.
251 ## - Source
Source Breast Journal. 2022:1389539, 2022.
252 ## - Abbreviated Source
Abbreviated source Breast J. 2022:1389539, 2022.
253 ## - Journal Name
Journal name The breast journal
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2022
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2023
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status epublish
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Medline status MEDLINE
266 ## - Date added to catalog
Date added to catalog 2022-10-20
520 ## - SUMMARY, ETC.
Abstract Background: Triple-antibiotic irrigation of breast implant pockets is a mainstay of infection prophylaxis in breast reconstruction and augmentation. The recall of bacitracin for injection due to risk of anaphylaxis and nephrotoxicity in January 2020, a staple component of the irrigation solution, has raised concern for worsened postoperative sequelae. This study aimed to investigate pre- and post-recall implant-based breast surgery to analyze the impact of bacitracin in irrigation solutions on infection rates.
520 ## - SUMMARY, ETC.
Abstract Conclusions: Despite the recent recall of bacitracin from inclusion in breast pocket irrigation solutions, our study demonstrated no detrimental impact on immediate complication rates. This shift in irrigation protocols calls for additional investigations into optimizing antibiotic combinations in solution, as bacitracin is no longer a viable option, to improve surgical outcomes and long-term benefits. Copyright © 2022 Abigail R. Tirrell et al.
520 ## - SUMMARY, ETC.
Abstract Methods: All implant-based breast reconstruction or augmentation surgeries from January 2019 to February 2021 were retrospectively reviewed. In a regression discontinuity study design, patients were divided into pre- and post-recall groups. Patient demographics, surgical details, and outcomes including infection rates were collected. Differences in complication rates were compared between groups and with surgical and patient factors.
520 ## - SUMMARY, ETC.
Abstract Results: 254 implants in 143 patients met inclusion criteria for this study, with 172 implants placed before recall and 82 placed after recall. Patients in each cohort did not differ in age, BMI, smoking status, or history of breast radiation or capsular contracture (p > 0.05). All breast pockets were irrigated with antibiotic solution, most commonly bacitracin, cefazolin, gentamycin, and povidone-iodine before recall (116,67.4%) and cefazolin, gentamycin, and povidone-iodine after recall (59,72.0%). There was no difference in incidence of infection (6.4% vs. 8.5%, p=0.551) or cellulitis (3.5% vs. 3.7%, p=0.959) before and after recall. Implant infection was associated with smoking history (p < 0.001) and increased surgical time (p=0.003).
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Breast Implants
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Breast Neoplasms
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Anti-Bacterial Agents/ae [Adverse Effects]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Bacitracin/ae [Adverse Effects]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Breast Neoplasms/dt [Drug Therapy]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cefazolin
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Gentamicins
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Povidone-Iodine/tu [Therapeutic Use]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Retrospective Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Treatment Outcome
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Washington Hospital Center
656 ## - INDEX TERM--OCCUPATION
Department MedStar Georgetown University Hospital/MedStar Washington Hospital Center
656 ## - INDEX TERM--OCCUPATION
Department Plastic Surgery Residency
656 ## - INDEX TERM--OCCUPATION
Department Surgery/Plastic Surgery
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Bekeny, Jenna
Institution Code MGUH
Program Plastic Surgery Residency
Degree MD
Resident year Resident PGY 2
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Fan, Kenneth L
Institution Code MWHC
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Tefera, Eshetu A
Institution Code MHRI
790 ## - Authors
All authors Bekeny JC, Fan KL, Song DH, Tefera EA, Tirrell AR
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1155/2022/1389539">https://dx.doi.org/10.1155/2022/1389539</a>
Public note https://dx.doi.org/10.1155/2022/1389539
858 ## - ORCID
ORCID text Bekeny, Jenna C
-- Fan, Kenneth L
-- Tefera, Eshetu A
Orcid <a href="https://orcid.org/0000-0002-7517-4326">https://orcid.org/0000-0002-7517-4326</a>
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-- https://orcid.org/0000-0001-5951-5576
-- https://orcid.org/0000-0001-5041-8438
858 ## - ORCID
ORCID text Bekeny, Jenna C
-- Fan, Kenneth L
-- Tefera, Eshetu A
Orcid <a href="https://orcid.org/0000-0002-7517-4326">https://orcid.org/0000-0002-7517-4326</a>
-- <a href="https://orcid.org/0000-0001-5951-5576">https://orcid.org/0000-0001-5951-5576</a>
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Name https://orcid.org/0000-0002-7517-4326
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858 ## - ORCID
ORCID text Bekeny, Jenna C
-- Fan, Kenneth L
-- Tefera, Eshetu A
Orcid <a href="https://orcid.org/0000-0002-7517-4326">https://orcid.org/0000-0002-7517-4326</a>
-- <a href="https://orcid.org/0000-0001-5951-5576">https://orcid.org/0000-0001-5951-5576</a>
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Name https://orcid.org/0000-0002-7517-4326
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-- https://orcid.org/0000-0002-7517-4326
-- https://orcid.org/0000-0001-5951-5576
-- https://orcid.org/0000-0001-5041-8438
-- https://orcid.org/0000-0002-7517-4326
-- https://orcid.org/0000-0001-5951-5576
-- https://orcid.org/0000-0001-5041-8438
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 10/20/2022   36105366 36105366 10/20/2022 10/20/2022 Journal Article

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