MARC details
| 000 -LEADER |
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| fixed length control field |
03197nam a22003857a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191204s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0149-5992 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.2337/dc19-0901 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
dc19-0901 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PMC6804613 [pmc] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
31391203 |
| 245 ## - TITLE STATEMENT |
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| Title |
Baseline Characteristics of Randomized Participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). |
| 251 ## - Source |
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| Source |
Diabetes Care. 42(11):2098-2107, 2019 Nov. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Diabetes Care. 42(11):2098-2107, 2019 Nov. |
| 253 ## - Journal Name |
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| Journal name |
Diabetes care |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2020 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2019-12-04 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: The GRADE cohort represents patients with T2DM treated with metformin requiring a second diabetes medication. GRADE will inform decisions about the clinical effectiveness of the addition of four classes of diabetes medications to metformin. Copyright (c) 2019 by the American Diabetes Association. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
OBJECTIVE: GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) is a 36-center unmasked, parallel treatment group, randomized controlled trial evaluating four diabetes medications added to metformin in people with type 2 diabetes (T2DM). We report baseline characteristics and compare GRADE participants to a National Health and Nutrition Examination Survey (NHANES) cohort. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
RESEARCH DESIGN AND METHODS: Participants were age >=30 years at the time of diagnosis, with duration of T2DM <10 years, HbA1c 6.8-8.5% (51-69 mmol/mol), prescribed metformin monotherapy, and randomized to glimepiride, sitagliptin, liraglutide, or insulin glargine. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
RESULTS: At baseline, GRADE's 5,047 randomized participants were 57.2 +/- 10.0 years of age, 63.6% male, with racial/ethnic breakdown of 65.7% white, 19.8% African American, 3.6% Asian, 2.7% Native American, 7.6% other or unknown, and 18.4% Hispanic/Latino. Duration of diabetes was 4.2 +/- 2.8 years, with mean HbA1c of 7.5 +/- 0.5% (58 +/- 5.3 mmol/mol), BMI of 34.3 +/- 6.8 kg/m2, and metformin dose of 1,944 +/- 204 mg/day. Among the cohort, 67% reported a history of hypertension, 72% a history of hyperlipidemia, and 6.5% a history of heart attack or stroke. Applying GRADE inclusion criteria to NHANES indicates enrollment of a representative cohort with T2DM on metformin monotherapy (NHANES cohort average age, 57.9 years; mean HbA1c, 7.4% [57 mmol/mol]; BMI, 33.2 kg/m2; duration, 4.2 +/- 2.5 years; and 7.2% with a history of cardiovascular disease). |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Aroda, Vanita R |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Kuhn, Alexander |
| 790 ## - Authors |
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| All authors |
Aroda VR, Crandall JP, Florez HJ, GRADE Research Group, Hox SH, Krause-Steinrauf H, Kuhn A, Sood A, Underkofler C, Wexler DJ |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.2337/dc19-0901">https://dx.doi.org/10.2337/dc19-0901</a> |
| Public note |
https://dx.doi.org/10.2337/dc19-0901 |
| 858 ## - ORCID |
|---|
| ORCID text |
Aroda, Vanita R |
| Orcid |
<a href="http://orcid.org/0000-0002-7706-4585">http://orcid.org/0000-0002-7706-4585</a> |
| Name |
http://orcid.org/0000-0002-7706-4585 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
