MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03682nam a22006977a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
200709s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
0022-4790 |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1002/jso.25875 [doi] |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| PMID |
32115718 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Differentiated thyroid cancer and Hashimoto thyroiditis: Utility of the Afirma gene expression classifier. |
| 251 ## - Source |
|---|
| Source |
Journal of Surgical Oncology. 121(7):1053-1057, 2020 Jun. |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
J Surg Oncol. 121(7):1053-1057, 2020 Jun. |
| 252 ## - Abbreviated Source |
|---|
| Former abbreviated source |
J Surg Oncol. 121(7):1053-1057, 2020 Jun. |
| 253 ## - Journal Name |
|---|
| Journal name |
Journal of surgical oncology |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Year |
2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Manufacturer |
FY2020 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
|---|
| Publication status |
ppublish |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2020-07-09 |
| 268 ## - Previous citation |
|---|
| -- |
Journal of Surgical Oncology. 121(7):1053-1057, 2020 Jun. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
BACKGROUND AND OBJECTIVES: The Afirma gene expression classifier (AGEC) has not been tested or validated in a high-risk group, such as patients with Hashimoto's thyroiditis (HT). We hypothesized that AGEC would perform worse in patients with HT. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
CONCLUSIONS: We observed a lower NPV for AGEC to rule out thyroid cancer in patients with HT, which reduces the utility of the test for this population. Copyright (c) 2020 Wiley Periodicals, Inc. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
METHODS: A retrospective review of patient charts in a single academic institution who underwent thyroidectomy between 2012 and 2017 was conducted. Patients with HT who underwent AGEC were identified to calculate sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
RESULTS: We identified 69 patients with HT and atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) on cytology who underwent AGEC analysis. The mean age of AGEC cohort was 50 years (range, 26-77 years) with 90% female. The median nodule size was 1.9 cm (interquartile range [IQR], 1.2-2.7 cm). Of the 69 patients, 62 showed suspicious AGEC of which 26 showed TC on surgical pathology. Of the seven benign AGEC, two showed TC on surgical pathology. The sensitivity, specificity, PPV, and NPV were 93%, 12%, 42%, and 71%, respectively. Of the entire AGEC cohort, 17 (43%) showed multicentric disease. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Hashimoto Disease/ge [Genetics] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
*Thyroid Neoplasms/ge [Genetics] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Adult |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cohort Studies |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Female |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Gene Expression Profiling/mt [Methods] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Hashimoto Disease/pa [Pathology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Hashimoto Disease/su [Surgery] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Male |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Middle Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Reproducibility of Results |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Retrospective Studies |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Thyroid Neoplasms/pa [Pathology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Thyroid Neoplasms/su [Surgery] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Thyroid Nodule/ge [Genetics] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Thyroid Nodule/pa [Pathology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Thyroid Nodule/su [Surgery] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Thyroidectomy |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Medicine/Endocrinology |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Pathology |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Surgery/Endocrine Surgery |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Surgery/General Surgery |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Felger, Erin A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Lee, Wen |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Papoian, Vardan |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Rosen, Jennifer E |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Wartofsky, Leonard |
| 790 ## - Authors |
|---|
| All authors |
Felger EA, Lee W, Papoian V, Rosen JE, Wartofsky L |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="https://dx.doi.org/10.1002/jso.25875">https://dx.doi.org/10.1002/jso.25875</a> |
| Public note |
https://dx.doi.org/10.1002/jso.25875 |
| 858 ## - ORCID |
|---|
| ORCID text |
Papoian, Vardan |
| Orcid |
<a href="http://orcid.org/0000-0002-2572-1483">http://orcid.org/0000-0002-2572-1483</a> |
| Name |
http://orcid.org/0000-0002-2572-1483 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
