MARC details
| 000 -LEADER |
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| fixed length control field |
03243nam a22003737a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
230316s20232023 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0270-9139 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
01515467-990000000-00284 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1097/HEP.0000000000000267 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
36651183 |
| 245 ## - TITLE STATEMENT |
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| Title |
Multi-Centered study of patient outcomes after declined for early liver transplantation in severe Alcohol-associated hepatitis. |
| 251 ## - Source |
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| Source |
Hepatology. 2023 Jan 19 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Hepatology. 2023 Jan 19 |
| 253 ## - Journal Name |
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| Journal name |
Hepatology (Baltimore, Md.) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2023 Jan 19 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Medline status |
Publisher |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
BACKGROUND: Early liver transplantation (LT) for alcohol-associated hepatitis (AH) is controversial in part because patients may recover, and obviate the need for LT. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: Liver recompensation is infrequent among severe AH patients declined for LT. Higher MELD-Na and age were associated with short-term mortality, while only history of failed alcohol rehabilitation was associated long-term mortality. The distinction between survival and liver recompensation merits further attention. Copyright © 2023 American Association for the Study of Liver Diseases. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: In this retrospective study among 5 ACCELERATE-AH sites, we randomly sampled patients evaluated and then declined for LT for AH. All had MELD>20 and<6 months of abstinence. Recompensation was defined as MELD<15 without variceal bleeding, ascites or overt hepatic encephalopathy requiring treatment. Multi-level mixed effects linear regression was used to calculate probabilities of recompensation; multivariable Cox regression was used for mortality analyses. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: Among 145 patients (61% men; median abstinence time and MELD-Na was 33 days [IQR 13-70] and 31 [IQR 26-36], respectively), 56% were declined for psychosocial reasons. Probability of 30-day, 90-day, 6-month, and 1-year survival were 76% (95%CI: 68-82%), 59% (95%CI: 50-66%), 49% (95%CI: 40-57%), and 46% (95%CI: 37-55%), respectively. Probability of 1-year recompensation was low at 10.0% (95%CI: 4.5-15.4%). Among patients declined due to clinical improvement, 1-year probability of recompensation was 28.0% (95%CI: 5.7-50.3%). Among survivors, median MELD-Na at 30-days, 90-days, and 1-year were: 29 (IQR 22-38), 19 (IQR 14-29), and 11 (IQR 7-17). Increased MELD-Na (aHR1.13, P<0.001) and age (aHR1.03, P<0.001) were associated with early (<=90 d) death, and only history of failed alcohol rehabilitation (aHR1.76, P=0.02) was associated with late death. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Ophthalmology Residency |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Davis, William |
| Institution Code |
MWHC |
| Program |
Ophthalmology Residency |
| Degree |
MD |
| Resident year |
Resident PGY 3 |
| 790 ## - Authors |
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| All authors |
Hsu CC |
| -- |
Dodge JL |
| -- |
Weinberg E |
| -- |
Im G |
| -- |
Ko J |
| -- |
Davis W |
| -- |
Rutledge S |
| -- |
Dukewich M |
| -- |
Shoreibah M |
| -- |
Aryan M |
| -- |
Vosooghi A |
| -- |
Lucey M |
| -- |
Rice J |
| -- |
Terrault NA |
| -- |
Lee BP |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1097/HEP.0000000000000267">https://dx.doi.org/10.1097/HEP.0000000000000267</a> |
| Public note |
https://dx.doi.org/10.1097/HEP.0000000000000267 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Journal Article |
