MARC details
| 000 -LEADER |
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| fixed length control field |
02283nam a22003257a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
130912s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0210-5705 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
22093607 |
| 245 ## - TITLE STATEMENT |
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| Title |
Genetic factors associated with the presence and progression of nonalcoholic fatty liver disease: a narrative review. [Review] |
| 251 ## - Source |
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| Source |
Gastroenterologia y Hepatologia. 35(1):32-41, 2012 Jan. |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
Gastroenterol Hepatol. 35(1):32-41, 2012 Jan. |
| 253 ## - Journal Name |
|---|
| Journal name |
Gastroenterologia y hepatologia |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2013-09-17 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Whereas insulin resistance and obesity are considered major risk factors for the development and progression of NAFLD, the genetic underpinnings are unclear. Before 2008, candidate gene studies based on prior knowledge of pathophysiology of fatty liver yielded conflicting results. In 2008, Romeo et al. published the first genome wide association study and reported the strongest genetic signal for the presence of fatty liver (PNPLA3, patatin-like phospholipase domain containing 3; rs738409). Since then, two additional genome wide scans were published and identified 9 additional genetic variants. Whereas these results shed light into the understanding of the genetics of NAFLD, most of associations have not been replicated in independent samples and, therefore, remain undetermined the significance of these findings. This review aims to summarize the understanding of genetic epidemiology of NAFLD and highlights the gaps in knowledge. Copyright 2011 Elsevier Espana, S.L. All rights reserved. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Fatty Liver/ge [Genetics] |
| 9 (RLIN) |
873 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Disease Progression |
| 9 (RLIN) |
468 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Genome-Wide Association Study |
| 9 (RLIN) |
874 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Humans |
| 9 (RLIN) |
11 |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Medicine/Gastroenterology |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Research Support, Non-U.S. Gov't |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Review |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Hernaez, Ruben |
| 9 (RLIN) |
872 |
| 790 ## - Authors |
|---|
| All authors |
Hernaez R |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="http://dx.doi.org/10.1016/j.gastrohep.2011.08.002">http://dx.doi.org/10.1016/j.gastrohep.2011.08.002</a> |
| Public note |
http://dx.doi.org/10.1016/j.gastrohep.2011.08.002 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Journal article |
| Source of classification or shelving scheme |
Other/Generic Classification Scheme |
