A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. (Record no. 12142)

MARC details
000 -LEADER
fixed length control field 04966nam a22004457a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130912s20132013 xxu||||| |||| 00| 0 eng dOvid Technologies
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1061-4036
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 23583978
245 ## - TITLE STATEMENT
Title A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
251 ## - Source
Source Nature Genetics. 45(6):690-6, 2013 Jun.
252 ## - Abbreviated Source
Abbreviated source Nat Genet. 45(6):690-6, 2013 Jun.
253 ## - Journal Name
Journal name Nature genetics
266 ## - Date added to catalog
Date added to catalog 2013-09-17
520 ## - SUMMARY, ETC.
Abstract Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 x 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 x 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 x 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 x 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *African Americans/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Body Mass Index
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Obesity/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Case-Control Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Gene Frequency
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genetic Loci
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genetic Predisposition to Disease
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genome-Wide Association Study
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Linkage Disequilibrium
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Obesity/eh [Ethnology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Polymorphism, Single Nucleotide
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
657 ## - INDEX TERM--FUNCTION
Medline publication type Meta-Analysis
657 ## - INDEX TERM--FUNCTION
Medline publication type Research Support, N.I.H., Extramural
657 ## - INDEX TERM--FUNCTION
Medline publication type Research Support, N.I.H., Intramural
657 ## - INDEX TERM--FUNCTION
Medline publication type Research Support, Non-U.S. Gov't
657 ## - INDEX TERM--FUNCTION
Medline publication type Research Support, U.S. Gov't, Non-P.H.S.
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Howard, Barbara V
790 ## - Authors
All authors Ademola A, Adeyemo AA, AGEN Consortium, Aldrich MC, Allison MA, Ambrosone CB, Ambs S, Amos CI, Arnett DK, Atwood L, Bandera EV, Becker DM, Berndt SI, Bernstein L, Bielak LF, BioBank Japan Project, Blot WJ, Bock CH, Borecki IB, Bottinger EP, Bowden DW, Bradfield JP, Britton A, Broeckel U, Burke G, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chanock SJ, Chen F, Chen G, Chen GK, Chen WM, Chen YD, Chiang CW, Chu L, Coetzee GA, Cooper RS, Cushman M, Demerath E, Deming-Halverson SL, Ding J, Driver RW, Dubbert P, Duggan D, Edwards DR, Edwards TL, Evans MK, Feitosa MF, Feng Y, Fernandes JK, Fox C, Freedman BI, Garvey WT, Gilkeson GS, Gillanders EM, Goodman PJ, Gottesman O, Graff M, Grant SF, Guo X, Haiman CA, Hakonarson H, Haritunians T, Harris CC, Harris T, Henderson BE, Hennis AJ, Hernandez DG, Hirschhorn JN, Howard BV, Howard TD, Howard VJ, Hsing A, Hu JJ, Hunt KJ, Huo D, Ingles SA, Irvin MR, John EM, Johnson KC, Jordan JM, Kabagambe EK, Kamen DL, Kang SJ, Kardia SL, Keating BJ, Ketkar S, Kittles RA, Klein EA, Kolb S, Kolonel LN, Kooperberg C, Kuller LH, Kutlar A, Lange LA, Langefeld CD, Le Marchand L, Leske MC, Lettre G, Levin AM, Li G, Liu S, Liu Y, Lohman K, Loos RJ, Lotay V, Lu Y, Lyon H, Maixner W, Manson JE, McKnight B, McNeill LH, Meng YA, Millikan RC, Monda KL, Monroe KR, Moore JH, Morhason-Bello I, Mosley TH, Murphy AB, Mychaleckyj JC, N'diaye A, NABEC Consortium, Nadukuru R, Nalls MA, Nathanson KL, Nayak U, Nemesure B, Neslund-Dudas C, Neuhouser M, Ng MC, North KE, Nyante S, Ochs-Balcom H, Ogundiran TO, Ogunniyi A, Ojengbede O, Olopade OI, Padhukasahasram B, Palmer C, Palmer JR, Palmer ND, Papanicolaou GJ, Patel SR, Peters U, Pettaway CA, Peyser PA, Press MF, Psaty BM, Rampersaud E, Rasmussen-Torvik LJ, Redline S, Reiner AP, Rhie SK, Rodriguez-Gil JL, Rotimi CN, Ruiz-Narvaez EA, Rybicki BA, Salako B, Sale MM, Schadt EE, Schreiner PJ, Schwartz AG, Shriner DA, Signorello LB, Singleton AB, Siscovick D, Smith SB, Speliotes EK, Spitz MR, Spruill IJ, Stanford JL, Strom SS, Sucheston L, Sun YV, Taylor H, Taylor KC, Tayo BO, Thun MJ, Tucker MA, UKBEC Consortium, Van Den Berg DJ, Vitolins M, Wang Z, Wassertheil-Smoller S, Wiencke JK, Williams LK, Williams SM, Winkler TW, Witte JS, Wojczynski MK, Wrensch M, Wu SY, Wu X, Yanek LR, Yang JJ, Young TR, Zakai NA, Zanetti KA, Zhao JH, Zhao W, Zheng W, Zheng Y, Zhou J, Zhu X, Ziegler RG, Zmuda JM, Zonderman AB
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="http://dx.doi.org/10.1038/ng.2608">http://dx.doi.org/10.1038/ng.2608</a>
Public note http://dx.doi.org/10.1038/ng.2608
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Journal article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Barcode Date last seen Date last checked out Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 09/17/2013 1 23583978 09/26/2017 09/26/2017 09/17/2013 Journal Article

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