MARC details
| 000 -LEADER |
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| fixed length control field |
03213nam a22003857a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160113s20142014 xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
25247997 |
| 245 ## - TITLE STATEMENT |
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| Title |
Magnesium depletion in patients treated with therapeutic hypothermia after cardiac arrest. |
| 251 ## - Source |
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| Source |
Therapeutic Hypothermia & Temperature Management. 4(4):188-92, 2014 Dec. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Ther. hypothermia temp. manag.. 4(4):188-92, 2014 Dec. |
| 253 ## - Journal Name |
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| Journal name |
Therapeutic hypothermia and temperature management |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2016-01-13 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Magnesium (Mg(2+)) depletion can have detrimental effects in postcardiac arrest patients through multiple potential mechanisms. Therapeutic hypothermia (TH) produces a Mg(2+) diuresis, but the effects of postcardiac arrest TH on serum Mg(2+) levels in patients with postcardiac arrest syndrome (PCAS) are yet to be systematically quantified. We conducted a retrospective chart review of 119 consecutive comatose PCAS patients treated with TH between 2005 and 2010 and compared them to 33 matched historic controls (HCs) seen at the same institution between 2002 and 2005 who were not treated with TH. We abstracted data from the first 96 hours postarrest, including date, time, and value of serum Mg(2+) levels and date, time, and amount of Mg(2+) repletion, along with outcomes at discharge. The median Mg(2+) level of TH patients was 2.0 mg/dL [interquartile range (IQR), 1.9-2.2 mg/dL] (0.82 mmol/L [IQR, 0.78-0.90 mmol/L]) versus 2.2 mg/dL [IQR, 1.9-2.4 mg/dL] (0.90 mmol/L [IQR, 0.82-0.99 mmol/L]) (p=0.2) in HCs. In addition, 42.9% (520/1214) of Mg(2+) levels in TH patients versus 31.9% (43/135) (p=0.014) in HC patients were below 2.0 mg/dL [0.82 mmol/L]. The average number of times the Mg(2+) level was checked in TH patients was 10.2 (range 1-18) versus 4.1 (range 1-10) in HCs. The TH patients were more likely to receive supplemental Mg(2+) than HCs (81.5% [97/119] vs. 27.3% [9/33] [p<0.01]). The mean supplemental Mg(2+) dose was 1.9 g for TH patients versus 0.5 g for HC patients. Mortality in patients treated with TH was 53.1% (60/113) versus 78.6% (22/28) (p=0.014) in HCs. Low serum Mg(2+) levels with subsequent Mg(2+) supplementation were more common in comatose patients with PCAS treated with TH compared to normothermic HC patients. The effect of untreated hypomagnesemia on postcardiac arrest outcomes remains to be determined. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Heart Arrest/bl [Blood] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Heart Arrest/th [Therapy] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Hypothermia, Induced/ae [Adverse Effects] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Magnesium/bl [Blood] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adult |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Female |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Male |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Middle Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Randomized Controlled Trials as Topic |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Retrospective Studies |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Emergency Medicine |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Mazer-Amirshahi, Maryann |
| 790 ## - Authors |
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| All authors |
Gaieski DF, Grossestreuer AV, Mazer-Amirshahi M, Neumar RW, Perman SM |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="http://dx.doi.org/10.1089/ther.2014.0012">http://dx.doi.org/10.1089/ther.2014.0012</a> |
| Public note |
http://dx.doi.org/10.1089/ther.2014.0012 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Journal article |
