MARC details
| 000 -LEADER |
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| fixed length control field |
03301nam a22004097a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
230721s20232023 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1178-7074 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.2147/IJGM.S407683 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
407683 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PMC10278858 [pmc] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
37342408 |
| 245 ## - TITLE STATEMENT |
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| Title |
Development and Validation of an Algorithm for Thrombosis with Thrombocytopenia Syndrome (TTS) at Unusual Sites. |
| 251 ## - Source |
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| Source |
International journal of general medicine. 16:2461-2467, 2023. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Int J Gen Med. 16:2461-2467, 2023. |
| 253 ## - Journal Name |
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| Journal name |
International journal of general medicine |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2023 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
epublish |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Medline status |
PubMed-not-MEDLINE |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2023-07-21 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Discussion: This study represents the first report of a validated ICD-10-CM-based algorithm for unusual site TTS. A validation effort found that the algorithm performed at an intermediate-to-high PPV, suggesting that the algorithm can be used in observational studies including active surveillance of COVID-19 vaccines and other medical products. Copyright © 2023 Hobbi et al. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Introduction: Thrombosis with thrombocytopenia syndrome (TTS) has been reported following receipt of adenoviral vector-based COVID-19 vaccines. However, no validation studies evaluating the accuracy of International Classification of Diseases-10-Clinical Modification (ICD-10-CM)-based algorithm for unusual site TTS are available in the published literature. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Methods: The purpose of this study was to assess the performance of clinical coding to 1) leverage literature review and clinical input to develop an ICD-10-CM-based algorithm to identify unusual site TTS as a composite outcome and 2) validate the algorithm against the Brighton Collaboration's interim case definition using laboratory, pathology, and imaging reports in an academic health network electronic health record (EHR) within the US Food and Drug Administration (FDA) Biologics Effectiveness and Safety (BEST) Initiative. Validation of up to 50 cases per thrombosis site was conducted, with positive predictive values (PPV) and 95% confidence intervals (95% CI) calculated using pathology or imaging results as the gold standard. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Results: The algorithm identified 278 unusual site TTS cases, of which 117 (42.1%) were selected for validation. In both the algorithm-identified and validation cohorts, over 60% of patients were 56 years or older. The positive predictive value (PPV) for unusual site TTS was 76.1% (95% CI 67.2-83.2%) and at least 80% for all but one individual thrombosis diagnosis code. PPV for thrombocytopenia was 98.3% (95% CI 92.1-99.5%). |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Indexing |
Automated |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
National Center for Human Factors in Healthcare |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Hettinger, Aaron Z |
| Institution Code |
NCHF |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Shenoy, Aarthi |
| Institution Code |
MHRI |
| 790 ## - Authors |
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| All authors |
Anderson SA, Beers J, Burrell T, Hettinger A, Hobbi S, Lloyd PC, Moll K, Saunders-Hastings P, Shenoy A, Shoaibi A, Srikrishnan A, Wong HL, Zhou CK |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.2147/IJGM.S407683">https://dx.doi.org/10.2147/IJGM.S407683</a> |
| Public note |
https://dx.doi.org/10.2147/IJGM.S407683 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
