MARC details
| 000 -LEADER |
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| fixed length control field |
02959nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
230628s20232023 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0935-9648 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1002/adma.202212190 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
36965107 |
| 245 ## - TITLE STATEMENT |
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| Title |
Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment. |
| 251 ## - Source |
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| Source |
Advanced Materials. :e2212190, 2023 Mar 25 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Adv. mater.. :e2212190, 2023 Mar 25 |
| 253 ## - Journal Name |
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| Journal name |
Advanced materials (Deerfield Beach, Fla.) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2023 Mar 25 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Medline status |
Publisher |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2023-06-28 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Heart rhythm disorders, known as arrhythmias, cause significant morbidity and are one of the leading causes of mortality. Cardiac arrhythmias are frequently treated by implantable devices, such as pacemakers and defibrillators, or by ablation therapy guided by electroanatomical mapping. Both implantable and ablation therapies require sophisticated biointerfaces for electrophysiological measurements of electrograms and delivery of therapeutic stimulation or ablation energy. In this work, a graphene biointerface for in vivo cardiac electrophysiology is reported for the first time. Leveraging sub-micrometer-thick tissue-conformable graphene arrays, sensing and stimulation of the open mammalian heart are demonstrated both in vitro and in vivo. Furthermore, the graphene biointerface treatment of atrioventricular block (the kind of arrhythmia where the electrical conduction from the atria to the ventricles is interrupted) is demonstrated. The graphene arrays show effective electrochemical properties, namely interface impedance down to 40 OMEGA cm2 at 1 kHz, charge storage capacity up to 63.7 mC cm-2 , and charge injection capacity up to 704 microC cm-2 . Transparency of the graphene structures allows for simultaneous optical mapping of cardiac action potentials, calcium transients, and optogenetic stimulation while performing electrical measurements and stimulation. The report presents evidence of the significant potential of graphene biointerfaces for advanced cardiac electrophysiology and arrhythmia therapy. Copyright � 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Indexing |
Automated |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Anesthesiology Residency |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
LaPiano, Jessica |
| Institution Code |
MGUH |
| Program |
Anesthesiology Residency |
| Degree |
MD |
| Resident year |
Resident PGY 1{}e=656 \\ |
| Local Authors |
MedStar Georgetown University Hospital/MedStar Washington Hospital Center |
| 790 ## - Authors |
|---|
| All authors |
Akinwande D, Chen Z, Efimov IR, Gupta S, Kireev D, LaPiano J, Lin Z, Liu N, Obaid SN |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1002/adma.202212190">https://dx.doi.org/10.1002/adma.202212190</a> |
| Public note |
https://dx.doi.org/10.1002/adma.202212190 |
| 858 ## - ORCID |
|---|
| Name |
https://orcid.org/0000-0002-7093-359X |
| ORCID text |
LaPiano, Jessica |
| Orcid |
<a href="https://orcid.org/0000-0002-7093-359X">https://orcid.org/0000-0002-7093-359X</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
