MARC details
| 000 -LEADER |
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| fixed length control field |
03270nam a22005777a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
230727s20232023 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0012-6667 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s40265-023-01887-4 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s40265-023-01887-4 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
37254024 |
| 245 ## - TITLE STATEMENT |
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| Title |
Guideline-Directed Medical Therapy for the Treatment of Heart Failure with Reduced Ejection Fraction. [Review] |
| 251 ## - Source |
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| Source |
Drugs. 83(9):747-759, 2023 Jun. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Drugs. 83(9):747-759, 2023 Jun. |
| 253 ## - Journal Name |
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| Journal name |
Drugs |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2023 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2023 Jun |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Medline status |
MEDLINE |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2023-07-27 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Guideline-directed medical therapy (GDMT) is the cornerstone of pharmacological therapy for patients with heart failure with reduced ejection fraction (HFrEF) and consists of the four main drug classes: renin-angiotensin system inhibitors, evidence-based beta-blockers, mineralocorticoid inhibitors and sodium glucose cotransporter 2 inhibitors. The recommendation for use of GDMT is based on the results of multiple major randomized controlled trials demonstrating improved clinical outcomes in patients with HFrEF who are maintained on this therapy. The effect is most beneficial when medications from the four main drug classes are used in conjunction. Despite this, there is an underutilization of GDMT, partially due to lack of awareness of how to safely and effectively initiate and titrate these medications. In this review article, we describe the different drug classes included in GDMT and offer an approach to initiation and effective titration in both the inpatient as well as outpatient setting. Copyright © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Diabetes Mellitus, Type 2 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Heart Failure |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Sodium-Glucose Transporter 2 Inhibitors |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adrenergic beta-Antagonists/pd [Pharmacology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adrenergic beta-Antagonists/tu [Therapeutic Use] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Angiotensin Receptor Antagonists/pd [Pharmacology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Angiotensin Receptor Antagonists/tu [Therapeutic Use] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Angiotensin-Converting Enzyme Inhibitors/pd [Pharmacology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Angiotensin-Converting Enzyme Inhibitors/tu [Therapeutic Use] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Diabetes Mellitus, Type 2/dt [Drug Therapy] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Heart Failure/dt [Drug Therapy] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Sodium-Glucose Transporter 2 Inhibitors/tu [Therapeutic Use] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Stroke Volume |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Indexing |
Automated |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Heart & Vascular Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Cardiovascular Disease Fellowship |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Review |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Lam, Phillip H |
| Institution Code |
MHVI |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Patel, Jay |
| Institution Code |
MWHC |
| Program |
Cardiovascular Disease Fellowship |
| Degree |
MD |
| Resident year |
Fellow PGY 5 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Rassekh, Negin |
| Institution Code |
MHVI |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Sheikh, Farooq H |
| Institution Code |
MHVI |
| 790 ## - Authors |
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| All authors |
Ahmed A, Deedwania P, Fonarow GC, Lam PH, Patel J, Rassekh N, Sheikh FH |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1007/s40265-023-01887-4">https://dx.doi.org/10.1007/s40265-023-01887-4</a> |
| Public note |
https://dx.doi.org/10.1007/s40265-023-01887-4 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
