Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. (Record no. 3523)
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000 -LEADER | |
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fixed length control field | 06601nam a22006017a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 180706s20182018 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
International Standard Serial Number | 1932-6203 |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1371/journal.pone.0198166 [doi] |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | PMC6005576 [pmc] |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | PONE-D-18-04838 [pii] |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
PMID | 29912962 |
245 ## - TITLE STATEMENT | |
Title | Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. |
251 ## - Source | |
Source | PLoS ONE [Electronic Resource]. 13(6):e0198166, 2018. |
252 ## - Abbreviated Source | |
Abbreviated source | PLoS ONE. 13(6):e0198166, 2018. |
253 ## - Journal Name | |
Journal name | PloS one |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Year | 2018 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Manufacturer | FY2018 |
266 ## - Date added to catalog | |
Date added to catalog | 2018-07-06 |
501 ## - WITH NOTE | |
Local holdings | Available online through MWHC library: 2006 - present |
520 ## - SUMMARY, ETC. | |
Abstract | Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in =131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P < 1.0 x 10-5). In Stage 2, these SNVs were tested for independent external replication in =440K individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10-8). For African ancestry samples, we detected 18 potentially novel BP loci (P < 5.0 x 10-8) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2) have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension. |
546 ## - LANGUAGE NOTE | |
Language note | English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Alcohol Drinking/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Alcohol Drinking/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Blood Pressure/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Continental Population Groups |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Hypertension/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Hypertension/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Polymorphism, Single Nucleotide |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Adolescent |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Adult |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Aged, 80 and over |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Cohort Studies |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Continental Population Groups/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Continental Population Groups/sn [Statistics & Numerical Data] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Female |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Gene-Environment Interaction |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Genetic Predisposition to Disease/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Genetic Predisposition to Disease/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Genome-Wide Association Study |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Male |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Middle Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Pedigree |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Young Adult |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
Institution | MedStar Health Research Institute |
657 ## - INDEX TERM--FUNCTION | |
Medline publication type | Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Howard, Barbara V |
790 ## - Authors | |
All authors | Afaq S, Alver M, Amin N, Amini M, Arking DE, Aschard H, Aung T, Bartz TM, Becker DM, Bentley AR, Bielak LF, Boehnke M, Boerwinkle E, Boissel M, Borecki I, Bouchard C, Bowden DW, Broeckel U, Brown M, Brown MR, Brumat M, Burke GL, Cai Q, Campbell A, Canouil M, Caulfield MJ, Chai JF, Chakravarti A, Chambers JC, Charumathi S, Chasman DI, Chen X, Cheng CY, Christensen K, Connell JM, Correa A, Cupples LA, de Las Fuentes L, de Mutsert R, de Silva HJ, Deary IJ, Deng X, Ding J, Divers J, Dorajoo R, Duan Q, Eaton CB, Ehret G, Elliott P, Eppinga RN, Esko T, Evangelou E, Evans MK, Farrall M, Faul JD, Feitosa MF, Felix SB, Fisher V, Fornage M, Forouhi NG, Forrester T, Fox ER, Franceschini N, Franco OH, Franks PW, Freedman BI, Friedlander Y, Froguel P, Gandin I, Gao C, Gao H, Gasparini P, Gauderman WJ, Ghanbari M, Gieger C, Gigante B, Goel A, Gu CC, Gu D, Gudnason V, Guo X, Hagemeijer Y, Hagenaars SP, Hallmans G, Harris SE, Harris TB, Hartwig FP, Hayward C, He J, He M, Heikkinen S, Heng CK, Hirata M, Horimoto ARVR, Horta BL, Howard BV, Hsu FC, Ida Chen YD, Ikram MA, InterAct Consortium, Jackson AU, John U, Jonas JB, Kahonen M, Kamatani Y, Kardia SLR, Kasturiratne A, Kato N, Katsuya T, Kelly TN, Khor CC, Kilpelainen TO, Koh WP, Komulainen P, Kooner JS, Kooperberg C, Kraja AT, Krieger JE, Kritchevsky SB, Kubo M, Kuhnel B, Kutalik Z, Kuusisto J, Laakso M, Laguzzi F, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Laurie CC, Leander K, Lehne B, Lehtimaki T, Levy D, Lewis CE, Li C, Li Y, Lin S, Liu J, Liu J, Liu Y, Loh M, Lohman KK, Louie T, Luan J, Magi R, Magnusson PKE, Manning AK, Marten J, Matoba N, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Momozawa Y, Mook-Kanamori DO, Morrison AC, Munroe PB, Musani SK, Nalls MA, Nelson CP, Nolte IM, Noordam R, Norris JM, Ntalla I, O'Connell JR, Oldehinkel AJ, Padmanabhan S, Palmas W, Palmer ND, Pedersen NL, Penninx BWJH, Pereira AC, Perls T, Peters A, Peyser PA, Polasek O, Porteous DJ, Poulter N, Province MA, Psaty BM, Raffel LJ, Raitakari OT, Rankinen T, Rao DC, Rauramaa R, Riaz M, Rice K, Richard MA, Ridker PM, Robino A, Roll K, Rose LM, Rosendaal FR, Rotimi CN, Rotter JI, Rueedi R, Said MA, Samani NJ, Schmidt CO, Schreiner PJ, Schupf N, Schwander K, Scott J, Scott RA, Scott WR, Sever PS, Shi Y, Shu XO, Sidney S, Sim X, Sims M, Sitlani CM, Smith AV, Smith JA, Snieder H, Sofer T, Sotoodehnia N, Stancakova A, Starr JM, Strauch K, Stringham HM, Study LC, Sung YJ, Tai ES, Tajuddin SM, Takeuchi F, Tan NYQ, Tang H, Taylor KD, Tayo BO, Teo YY, Tham YC, Turner ST, Uitterlinden AG, van Dam RM, van der Harst P, van der Most PJ, van Duijn CM, Varga TV, Vitart V, Vojinovic D, Vollenweider P, Wagenknecht LE, Waldenberger M, Wang L, Wang Y, Wang YX, Ware EB, Wareham NJ, Warren HR, Watkins H, Wei WB, Weir DR, Weiss S, Wen W, Wickremasinghe AR, Williams C, Winkler TW, Wojczynski MK, Wong TY, Wu T, Yanek LR, Yao J, Yu C, Yuan JM, Zhang W, Zhao JH, Zhao W, Zheng W, Zhu X, Zonderman AB |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
DOI | <a href="https://dx.doi.org/10.1371/journal.pone.0198166">https://dx.doi.org/10.1371/journal.pone.0198166</a> |
Public note | https://dx.doi.org/10.1371/journal.pone.0198166 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Koha item type | Journal Article |
Item type description | Article |
Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
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MedStar Authors Catalog | MedStar Authors Catalog | 07/06/2018 | 29912962 | 29912962 | 07/06/2018 | 07/06/2018 | Journal Article |