Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. (Record no. 4090)
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000 -LEADER | |
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fixed length control field | 06157nam a22005777a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 190314s20192019 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
International Standard Serial Number | 0002-9262 |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1093/aje/kwz005 [doi] |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | 5304469 [pii] |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
PMID | 30698716 |
245 ## - TITLE STATEMENT | |
Title | Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. |
251 ## - Source | |
Source | American Journal of Epidemiology. 188(6):1033-1054, 2019 06 01. |
252 ## - Abbreviated Source | |
Abbreviated source | Am J Epidemiol. 188(6):1033-1054, 2019 06 01. |
252 ## - Abbreviated Source | |
Former abbreviated source | Am J Epidemiol. 2019 Jan 29 |
253 ## - Journal Name | |
Journal name | American journal of epidemiology |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Year | 2019 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Manufacturer | FY2019 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
Publication status | aheadofprint |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
Publication status | ppublish |
266 ## - Date added to catalog | |
Date added to catalog | 2019-03-14 |
268 ## - Previous citation | |
-- | American Journal of Epidemiology. 2019 Jan 29 |
501 ## - WITH NOTE | |
Local holdings | Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006 |
520 ## - SUMMARY, ETC. | |
Abstract | An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multi-ancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in Stage 1 (genome-wide discovery) and 66 studies in Stage 2 (focused follow-up), for a total of 394,584 individuals from five ancestry groups. Genetic main and interaction effects were jointly assessed by a 2 degrees of freedom (DF) test, and a 1 DF test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10-6) with lipid levels in Stage 1 and were evaluated in Stage 2, followed by combined analyses of Stage 1 and Stage 2. In the combined analysis of Stage 1 and Stage 2, 147 independent loci were associated with lipid levels at P < 5 x 10-8 using 2 DF tests, of which 18 were novel. No genome-wide significant associations were found testing the interaction effect alone. The novel loci included several genes (PCSK5, VEGFB, and A1CF) with a putative role in lipid metabolism based on existing evidence from cellular and experimental models. |
546 ## - LANGUAGE NOTE | |
Language note | English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Alcohol Drinking/ep [Epidemiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Lipids/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Adolescent |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Adult |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Cholesterol, HDL/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Cholesterol, LDL/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Continental Population Groups |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Female |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Genome-Wide Association Study |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Genotype |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Life Style |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Male |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Middle Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Phenotype |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Triglycerides/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Vascular Endothelial Growth Factor B |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Young Adult |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
Institution | MedStar Health Research Institute |
657 ## - INDEX TERM--FUNCTION | |
Medline publication type | Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Howard, Barbara V |
790 ## - Authors | |
All authors | Afaq S, Alver M, Amin N, Amini M, Arking DE, Aschard H, Aung T, Ballantyne C, Bartz TM, Becker DM, Bentley AR, Bielak LF, Boehnke M, Boerwinkle E, Boissel M, Bouchard C, Bowden DW, Broeckel U, Brown MR, Campbell A, Canouil M, Chai JF, Chambers JC, Charumathi S, Chasman DI, Chen X, Chen YI, Cheng CY, Connell JM, Cupples LA, de Faire U, de Las Fuentes L, de Mutsert R, de Silva HJ, de Vries PS, Deary IJ, Deng X, Ding J, Divers J, Dominiczak AF, Dorajoo R, Duan Q, Eaton CB, Elliott P, Eppinga RN, Esko T, Evangelou E, Evans MK, Farrall M, Faul JD, Feitosa MF, Fisher V, Fornage M, Forrester T, Fox ER, Franceschini N, Franco OH, Franks PW, Freedman BI, Friedlander Y, Froguel P, Gandin I, Gao C, Gasparini P, Gauderman WJ, Ghanbari M, Gieger C, Giulianini F, Goel A, Grabe HJ, Graff M, Grove ML, Gu CC, Gudnason V, Guo X, Hagemeijer Y, Harris SE, Harris TB, Hartwig FP, Hayward C, He M, Heikkinen S, Heng CK, Hirata M, Hixson JE, Horimoto ARVR, Horta BL, Howard BV, Hsu FC, Huffman JE, Ikram MA, InterAct Consortium, Jackson AU, Jacobs DR Jr, Johnson C, Jonas JB, Kamatani Y, Kammerer CM, Kardia SLR, Kasturiratne A, Kato N, Katsuya T, Kelly TN, Khor CC, Kilpelainen TO, Koh WP, Koistinen HA, Kolcic I, Komulainen P, Kooner JS, Kooperberg C, Kraja AT, Krieger JE, Kritchevsky SB, Kubo M, Kuhnel B, Kuusisto J, Laakso M, Laguzzi F, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Leander K, Lee JH, Lehne B, Lehtimaki T, Lemaitre RN, Li C, Li Y, Liang J, Lifelines Cohort, Groningen, The Netherlands (Lifelines Cohort Study), Liu CT, Liu J, Liu J, Liu K, Liu Y, Loh M, Lohman KK, Louie T, Luan J, Lyytikainen LP, Magi R, Magnusson PKE, Manichaikul AW, Manning AK, Matoba N, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Mook-Kanamori DO, Morrison AC, Mosley TH Jr, Mukamal KJ, Munroe PB, Musani SK, Nalls MA, Nauck M, Nelson CP, Nolte IM, Noordam R, North KE, Ntalla I, O'Connell JR, Palmer ND, Pazoki R, Pedersen NL, Penninx B, Pereira AC, Peters A, Peyser PA, Pietzner M, Polasek O, Poulter N, Province MA, Psaty BM, Raffel LJ, Raitakari OT, Rankinen T, Rao DC, Rauramaa R, Reiner AP, Riaz M, Rice K, Rice TK, Rich SS, Richard MA, Ridker PM, Robino A, Robinson JG, Rose LM, Rotimi CN, Rotter JI, Rudan I, Said MA, Samani NJ, Schmidt CO, Schreiner PJ, Schwander K, Scott J, Scott RA, Scott WR, Sever P, Shi Y, Shu XO, Sidney S, Sim X, Sims M, Smith AV, Smith BH, Smith JA, Snieder H, Sofer T, Sotoodehnia N, Stancakova A, Starr JM, Strauch K, Sung YJ, Tai ES, Tajuddin SM, Takeuchi F, Tan N, Taylor KD, Tayo BO, Teo YY, Tham YC, Uitterlinden AG, van Dam RM, van der Harst P, van der Most PJ, van Duijn CM, van Heemst D, Varga TV, Vojinovic D, Vuckovic D, Wagenknecht LE, Waldenberger M, Wang L, Wang Y, Wang Y, Wang YX, Wang Z, Ware EB, Wareham NJ, Watkins H, Wei WB, Weir DR, Wen W, Wickremasinghe AR, Williams C, Wilson G Sr, Winkler TW, Wojczynski MK, Wong TY, Yanek LR, Yao J, Yu B, Yu C, Yuan JM, Zhang W, Zhao JH, Zhao W, Zheng W, Zhu X, Zonderman AB |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
DOI | <a href="https://dx.doi.org/10.1093/aje/kwz005">https://dx.doi.org/10.1093/aje/kwz005</a> |
Public note | https://dx.doi.org/10.1093/aje/kwz005 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Koha item type | Journal Article |
Item type description | Article |
Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
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MedStar Authors Catalog | MedStar Authors Catalog | 03/14/2019 | 30698716 | 30698716 | 03/14/2019 | 03/14/2019 | Journal Article |