Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia. (Record no. 4352)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02671nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190621s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2005-940X |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 30732431 |
| 245 ## - TITLE STATEMENT | |
| Title | Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia. |
| 251 ## - Source | |
| Source | Journal of Movement Disorders. 12(1):37-42, 2019 01. |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Journal mov. disorders.. 12(1):37-42, 2019 01. |
| 253 ## - Journal Name | |
| Journal name | Journal of movement disorders |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2019 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Publication status | ppublish |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2019-06-21 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | CONCLUSION: Less pulsatile levodopa with 6 daily doses was associated with a low incidence of LID. Further study of this method of treatment is warranted. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | METHODS: This is a retrospective cohort study of patients with Parkinson's disease at the movement disorders clinic of Medstar Washington Hospital Center. The study was not blinded or randomized. Patients were seen between August 2002 and August 2018. During these years, we treated patients with less pulsatile (6 doses daily) levodopa treatment to reduce LID. Occurrence of LID was recorded. |
| 520 ## - SUMMARY, ETC. | |
| Abstract | OBJECTIVE: To evaluate whether less pulsatile levodopa therapy (LPT) can reduce the development of levodopa-induced dyskinesia (LID). |
| 520 ## - SUMMARY, ETC. | |
| Abstract | RESULTS: Ninety-five patients with Parkinson's disease taking levodopa were divided into two groups: 1) patients who were initially managed on LPT or who switched from traditional therapy (TT) (n = 61) (mean disease duration: 7.7 +/- 4.8 years, mean levodopa duration: 5.6 +/- 4.5 years and mean observation time: 4.3 +/- 3.4 years), and 2) patients on TT throughout the observation period or until they developed dyskinesia (n = 34) (mean disease duration: 8.3 +/- 3.8 years, mean levodopa duration: 6.2 +/- 4.2 years and mean observation time: 4.1 +/- 3.4 years). Three of the 61 LPT patients developed dyskinesia during the observation period. One of the patients developed dyskinesia after being switched to pulsatile doses by another doctor. In the other two, dyskinesia was minimal. In contrast to this 4.9% cumulative incidence, dyskinesia occurred in 50% (17/34) of TT patients, an incidence similar to that in published data (p < 0.001). |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Neurology |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Laureno, Robert |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Lin, Mark M |
| 790 ## - Authors | |
| All authors | Laureno R, Lin MM |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| DOI | <a href="https://dx.doi.org/10.14802/jmd.18046">https://dx.doi.org/10.14802/jmd.18046</a> |
| Public note | https://dx.doi.org/10.14802/jmd.18046 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MedStar Authors Catalog | MedStar Authors Catalog | 06/21/2019 | 30732431 | 30732431 | 06/21/2019 | 06/21/2019 | Journal Article |