MARC details
| 000 -LEADER |
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| fixed length control field |
04319nam a22006377a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191010s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0010-7824 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1016/j.contraception.2019.09.001 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
S0010-7824(19)30413-5 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
31520608 |
| 245 ## - TITLE STATEMENT |
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| Title |
A factorial-design randomized controlled trial comparing misoprostol alone to Dilapan with misoprostol and comparing buccal to vaginal misoprostol for same-day cervical preparation prior to dilation & evacuation at 14weeks 0days-19weeks 6days gestation.. |
| 251 ## - Source |
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| Source |
Contraception. 100(6):445-450, 2019 12. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Contraception. 100(6):445-450, 2019 12. |
| 252 ## - Abbreviated Source |
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| Former abbreviated source |
Contraception. 2019 Sep 11 |
| 253 ## - Journal Name |
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| Journal name |
Contraception |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2020 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2019-10-10 |
| 268 ## - Previous citation |
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| -- |
Contraception. 2019 Sep 11 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: 1995 - present |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: Hygroscopic dilators with misoprostol requires more time and increases cervical dilation without shortening D&E time when used for cervical preparation 4-6h prior to D&E before 20weeks. Women receiving vaginal misoprostol may have more chills compared to buccal misoprostol. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
IMPLICATIONS: Adding hygroscopic dilators to misoprostol for same day D&E procedures at less than 20weeks gestation increases total intervention time without reducing D&E time and is less favored by patients. Clinical judgment requires balancing relative effectiveness with patient preference. Further studies should evaluate the side effect profile of vaginal misoprostol. Copyright (c) 2019. Published by Elsevier Inc. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
OBJECTIVES: To compare procedure times following same-day cervical preparation using misoprostol 400 mcg alone or misoprostol 400 mcg plus hygroscopic dilators for dilation and evacuation (D&E) before 20weeks gestation and to compare side effects of buccal and vaginal misoprostol administration. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: We randomized 163 women and 161 completed the study. We completed all procedures in one day. Mean total procedure time was 14.0 and 10.8min with and without hygroscopic dilators (difference 3.2min, 95% CI 1.7, 4.6). Mean D&E procedure time was 0.7 (95% CI -0.8, 2.1) minutes longer without hygroscopic dilators. Initial cervical dilation was 15.6 and 11.7mm with and without hygroscopic dilators (difference 3.9mm, 95% CI 3.1, 4.8). Participants receiving buccal misoprostol reported less chills (1.9) than women receiving vaginal misoprostol (2.3), p=.04. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
STUDY DESIGN: We randomized women undergoing D&E at 14weeks 0days to 19weeks 6days gestation to receive (1) hygroscopic dilators or not and (2) buccal or vaginal misoprostol using a 2x2 factorial design. We assessed two primary outcomes: (1) total procedure time, defined as time to insert hygroscopic dilators plus D&E time, and (2) side effects of misoprostol 4-6h after initiation of cervical preparation using a 5-point Likert scale assessing nausea, emesis, diarrhea, chills and cramps. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Abortifacient Agents, Nonsteroidal/ad [Administration & Dosage] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Abortion, Induced/mt [Methods] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Labor Stage, First/de [Drug Effects] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Misoprostol/ad [Administration & Dosage] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Polymers |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Abortifacient Agents, Nonsteroidal/ae [Adverse Effects] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Administration, Buccal |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Administration, Intravaginal |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adolescent |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adult |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Female |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Misoprostol/ae [Adverse Effects] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Pregnancy |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Young Adult |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Obstetrics and Gynecology |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Obstetrics and Gynecology/Family Planning |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Lotke, Pamela S |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Reeves, Matthew F |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Shakir-Reese, Jamilah M |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Ye, Peggy P |
| 790 ## - Authors |
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| All authors |
Lotke PS, Perritt JB, Reeves MF, Shakir-Reese JM, Ye PP |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1016/j.contraception.2019.09.001">https://dx.doi.org/10.1016/j.contraception.2019.09.001</a> |
| Public note |
https://dx.doi.org/10.1016/j.contraception.2019.09.001 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
