MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03285nam a22003737a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
191014s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
2053-8790 |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1136/lupus-2019-000349 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
lupus-2019-000349 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
PMC6762037 [pmc] |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| PMID |
31592328 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Randomised prospective trial to assess the clinical utility of multianalyte assay panel with complement activation products for the diagnosis of SLE. |
| 251 ## - Source |
|---|
| Source |
Lupus Science & Medicine. 6(1):e000349, 2019. |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
Lupus sci. med.. 6(1):e000349, 2019. |
| 253 ## - Journal Name |
|---|
| Journal name |
Lupus science & medicine |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Manufacturer |
FY2020 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
|---|
| Publication status |
epublish |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2019-10-14 |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Conclusion: Our data suggest that MAP/CB-CAPs testing has clinical utility in facilitating SLE diagnosis and treatment decisions. Copyright (c) Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Methods: Patients (n=145) with a history of positive antinuclear antibody status were evaluated clinically by rheumatologists and randomised to SDLT arm (tests ordered at the discretion of the rheumatologists) or to MAP/CB-CAPs testing arm. The primary endpoint was based on the change in the physician likelihood of SLE on a five-point Likert scale collected before and after testing. Changes in pharmacological treatment based on laboratory results were assessed in both arms. Statistical analysis consisted of Wilcoxon and Fisher's exact tests. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Objective: We compared the physician-assessed diagnostic likelihood of SLE resulting from standard diagnosis laboratory testing (SDLT) to that resulting from multianalyte assay panel (MAP) with cell-bound complement activation products (MAP/CB-CAPs), which reports a two-tiered index test result having 80% sensitivity and 86% specificity for SLE. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Results: At enrolment, patients randomised to SDLT (n=73, age=48+/-2 years, 94% females) and MAP/CB-CAPs testing arms (n=72, 50+/-2 years, 93% females) presented with similar pretest likelihood of SLE (1.42+/-0.06 vs 1.46+/-0.06 points, respectively; p=0.68). Post-test likelihood of SLE resulting from randomisation in the MAP/CB-CAPs testing arm was significantly lower than that resulting from randomisation to SDLT arm on review of test results (-0.44+/-0.10 points vs -0.19+/-0.07 points) and at the 12-week follow-up visit (-0.61+/-0.10 points vs -0.31+/-0.10 points) (p<0.05). Among patients randomised to the MAP/CB-CAPs testing arm, two-tiered positive test results associated significantly with initiation of prednisone (p=0.034). |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Medicine/Rheumatology |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Loupasakis, Konstantinos |
| 790 ## - Authors |
|---|
| All authors |
Alexander RV, Alper J, Dervieux T, Fondal M, Hojjati M, Ibarra C, Kataria R, Khosroshahi A, Loupasakis K, Massarotti E, Narain S, O'Malley T, Powell T, Sherrer Y, Wallace DJ, Weinstein A |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="https://dx.doi.org/10.1136/lupus-2019-000349">https://dx.doi.org/10.1136/lupus-2019-000349</a> |
| Public note |
https://dx.doi.org/10.1136/lupus-2019-000349 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
