MARC details
| 000 -LEADER |
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| fixed length control field |
02937nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201231s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1600-6135 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1111/ajt.16405 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
33226726 |
| 245 ## - TITLE STATEMENT |
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| Title |
CD69+ resident memory T cells are associated with graft-versus-host disease in intestinal transplantation. |
| 251 ## - Source |
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| Source |
American Journal of Transplantation. 2020 Nov 23 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Am J Transplant. 2020 Nov 23 |
| 253 ## - Journal Name |
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| Journal name |
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2021 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2020-12-31 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: May 2001 - present |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Graft-versus-host disease (GvHD) is a common, morbid complication after intestinal transplantation (ITx) with poorly-understood pathophysiology. Resident memory T cells (TRM ) are a recently described CD69+ memory T cell subset localizing to peripheral tissue. We observed that T effector memory cells (TEM ) in the blood increase during GvHD and hypothesized that they derive from donor graft CD69+TRM migrating into host blood and tissue. To probe this hypothesis, graft and blood lymphocytes from 10 ITx patients with overt GvHD and 34 without were longitudinally analyzed using flow cytometry. As hypothesized, CD4+ and CD8+CD69+TRM were significantly increased in blood and grafts of GvHD patients, alongside higher cytokine and activation marker expression. The majority of CD69+TRM were donor derived as determined by multiplex immunostaining. Notably, CD8/PD-1 was significantly elevated in blood prior to transplantation in patients who later had GvHD, and percentages of HLA-DR, CD57, PD-1, and naive T cells differed significantly between GvHD patients who died vs. those who survived. Overall, we demonstrate that (1) there were significant increases in TEM , at the time of GvHD, possibly of donor derivation; (2) donor TRM in the graft are a possible source; and (3) potential biomarkers for the development and prognosis of GvHD exist. Copyright This article is protected by copyright. All rights reserved. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Pathology and Laboratory Medicine |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Kang, Jiman |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Kwon, Dong Hyang |
| 790 ## - Authors |
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| All authors |
Duttargi A, Fishbein TM, Hawksworth J, Kallakury B, Kang J, Kara Balla A, Kaufman S, Khan K, Kroemer A, Kwon DH, Matsumoto CS, Moturi S, Pasieka HB, Pavletic S, Robson SC, Sadat M, Stovroff M, Subramanian S, Svetlicky N, Weiner J, Yazigi N, Zasloff M |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1111/ajt.16405">https://dx.doi.org/10.1111/ajt.16405</a> |
| Public note |
https://dx.doi.org/10.1111/ajt.16405 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
