Relative addictive potential of opioid analgesic agents.

MedStar author(s):
Citation: Pain Management. 11(2):201-215, 2021 Mar.PMID: 33300384Institution: MedStar Washington Hospital CenterDepartment: Emergency MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Analgesics, Opioid/ae [Adverse Effects] | *Drug Prescriptions/st [Standards] | *Fentanyl/ae [Adverse Effects] | *Opioid-Related Disorders/ge [Genetics] | *Oxycodone/ae [Adverse Effects] | *Pharmacogenetics | HumansYear: 2021ISSN:
  • 1758-1869
Name of journal: Pain managementAbstract: Opioid overdoses and deaths continue to be a problem in the USA with a significant portion related to prescribed opioid analgesic agents. The role of pharmacogentic factors in opioid addiction is an active area of research. While all opioid analgesic agents have some addictive potential, it is clear that there are some with greater addictive potential. Oxycodone is the most widely abused opioid analgesic and it appears to predispose to chronic use with high likability by users. Fentanyl and hydromorphone are both very lipophilic allowing rapid penetration into the CNS, but are not rated as highly as other agents. Providers should consider the risk of addiction with the opioids they prescribe and give those with a lower addictive potential.All authors: Connors NJ, Kim HK, Mazer-Amirshahi M, Motov SOriginally published: Pain Management. 2020 Dec 10Fiscal year: FY2021Digital Object Identifier: ORCID: Date added to catalog: 2020-12-31
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 33300384 Available 33300384

Opioid overdoses and deaths continue to be a problem in the USA with a significant portion related to prescribed opioid analgesic agents. The role of pharmacogentic factors in opioid addiction is an active area of research. While all opioid analgesic agents have some addictive potential, it is clear that there are some with greater addictive potential. Oxycodone is the most widely abused opioid analgesic and it appears to predispose to chronic use with high likability by users. Fentanyl and hydromorphone are both very lipophilic allowing rapid penetration into the CNS, but are not rated as highly as other agents. Providers should consider the risk of addiction with the opioids they prescribe and give those with a lower addictive potential.

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