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Lamotrigine-associated hemophagocytic lymphohistiocytosis.

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Citation: BMJ Case Reports. 14(1), 2021 Jan 06.PMID: 33408106Institution: MedStar Union Memorial HospitalForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Anticonvulsants/ad [Administration & Dosage] | *Lamotrigine/ae [Adverse Effects] | *Lymphohistiocytosis, Hemophagocytic/ci [Chemically Induced] | *Seizures/dt [Drug Therapy] | Adult | Biopsy | Bone Marrow/pa [Pathology] | Dexamethasone/tu [Therapeutic Use] | Diagnosis, Differential | Etoposide/tu [Therapeutic Use] | Humans | Lymphohistiocytosis, Hemophagocytic/bl [Blood] | Lymphohistiocytosis, Hemophagocytic/di [Diagnosis] | Lymphohistiocytosis, Hemophagocytic/dt [Drug Therapy] | MaleYear: 2021 ISSN:

1757-790X

Name of journal: BMJ case reportsAbstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disorder of excessive immune activation. It is mostly seen in the paediatric population and is rarely observed in adults. HLH can be inherited or acquired and is commonly triggered by activation of the immune system by an underlying viral infection or in immune system deficiency such as malignancy or underlying rheumatological disease. HLH is a difficult entity to diagnose due to the rarity of this disorder, variable clinical presentation and non-specific clinical and laboratory findings. HLH carries a high mortality if left untreated, and therefore prompt diagnosis and initiation of immunosuppressive, immunomodulatory and cytostatic medications are critical to improve survival in affected patients. Here, we present a case of lamotrigine-associated HLH. To our knowledge, only eight other cases of lamotrigine-associated HLH have been reported in adult patients. Copyright (c) BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.All authors: Ozdemirli M, Suleman N, Weisman DOriginally published: BMJ Case Reports. 14(1), 2021 Jan 06.Fiscal year: FY2021Digital Object Identifier:

https://dx.doi.org/10.1136/bcr-2020-238183

ORCID:

http://orcid.org/0000-0001-6537-7472 http://orcid.org/0000-0001-5082-8955 http://orcid.org/0000-0001-6537-7472 http://orcid.org/0000-0001-5082-8955
http://orcid.org/0000-0001-6537-7472 http://orcid.org/0000-0001-5082-8955 http://orcid.org/0000-0001-6537-7472 http://orcid.org/0000-0001-5082-8955

Date added to catalog: 2021-02-17

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Title notes ( 2 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	33408106	Available		33408106

Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disorder of excessive immune activation. It is mostly seen in the paediatric population and is rarely observed in adults. HLH can be inherited or acquired and is commonly triggered by activation of the immune system by an underlying viral infection or in immune system deficiency such as malignancy or underlying rheumatological disease. HLH is a difficult entity to diagnose due to the rarity of this disorder, variable clinical presentation and non-specific clinical and laboratory findings. HLH carries a high mortality if left untreated, and therefore prompt diagnosis and initiation of immunosuppressive, immunomodulatory and cytostatic medications are critical to improve survival in affected patients. Here, we present a case of lamotrigine-associated HLH. To our knowledge, only eight other cases of lamotrigine-associated HLH have been reported in adult patients. Copyright (c) BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.

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