Urinary Symptoms Are Unrelated to Leukocyte Esterase and Nitrite Among Indwelling Catheter Users.

MedStar author(s):
Citation: Topics in Spinal Cord Injury Rehabilitation. 29(1):82-93, 2023 Winter.PMID: 36819928Institution: MedStar Health Research Institute | MedStar National Rehabilitation NetworkDepartment: Physical Medicine & Rehabilitation ResidencyForm of publication: Journal ArticleMedline article type(s): Journal Article | Observational StudySubject headings: *Spinal Cord Diseases | *Spinal Cord Injuries | *Urinary Tract Infections | Catheters, Indwelling | Humans | Nitrites | Predictive Value of Tests | Prospective Studies | Urinary Bladder | Urinary Tract Infections/di [Diagnosis]Year: 2023Local holdings: Available in print through MWHC library: 1999 - Winter 2007ISSN:
  • 1082-0744
Name of journal: Topics in spinal cord injury rehabilitationAbstract: Conclusion: No association was observed between A, B1, and B2 symptoms and positive dipstick. A negative dipstick with the absence of key symptoms may better support clinical decision-making. Copyright ©2023 American Spinal Injury Association.Method: This was a prospective 12-month observational study of real-time self-administered urine dipstick results and symptoms in a community setting that included 52 spinal cord injury/disease (SCI/D) participants with neurogenic lower urinary tract dysfunction (NLUTD) who use an indwelling catheter. Symptoms were collected using the Urinary Symptom Questionnaire for Neurogenic Bladder-Indwelling Catheter (USQNB-IDC). The USQNB-IDC includes actionable (A), bladder (B1), urine quality (B2), and other (C) symptoms; analyses focused on A, B1, and B2 symptoms. Dipstick results include nitrite (NIT +/-), and leukocyte esterase (LE; negative, trace, small, moderate, or large). Dipstick outcomes were defined as strong positive (LE = moderate/large and NIT+), inflammation positive (LE = moderate/large and NIT-), negative (LE = negative/trace and NIT-), and indeterminate (all others).Objectives: To explore the association between dipstick results and urinary symptoms.Results: Nitrite positive dipsticks and moderate or large LE positive dipsticks were each observed in over 50% of the sample in every week. Strong positive dipstick results were observed in 35% to 60% of participants in every week. A, B1, or B2 symptoms co-occurred less than 50% of the time with strong positive dipsticks, but they also co-occurred with negative dipsticks. Participants were asymptomatic with a strong positive dipstick an average of 30.2% of the weeks. On average, 73% of the time a person had a negative dipstick, they also had no key symptoms (95% CI, .597-.865).All authors: Rounds AK, Tractenberg RE, Groah SL, Frost JK, Ljungberg IH, Navia H, Pham CTFiscal year: FY2023Digital Object Identifier: ORCID: Date added to catalog: 2023-04-11
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Journal Article MedStar Authors Catalog Article Available

Available in print through MWHC library: 1999 - Winter 2007

Conclusion: No association was observed between A, B1, and B2 symptoms and positive dipstick. A negative dipstick with the absence of key symptoms may better support clinical decision-making. Copyright ©2023 American Spinal Injury Association.

Method: This was a prospective 12-month observational study of real-time self-administered urine dipstick results and symptoms in a community setting that included 52 spinal cord injury/disease (SCI/D) participants with neurogenic lower urinary tract dysfunction (NLUTD) who use an indwelling catheter. Symptoms were collected using the Urinary Symptom Questionnaire for Neurogenic Bladder-Indwelling Catheter (USQNB-IDC). The USQNB-IDC includes actionable (A), bladder (B1), urine quality (B2), and other (C) symptoms; analyses focused on A, B1, and B2 symptoms. Dipstick results include nitrite (NIT +/-), and leukocyte esterase (LE; negative, trace, small, moderate, or large). Dipstick outcomes were defined as strong positive (LE = moderate/large and NIT+), inflammation positive (LE = moderate/large and NIT-), negative (LE = negative/trace and NIT-), and indeterminate (all others).

Objectives: To explore the association between dipstick results and urinary symptoms.

Results: Nitrite positive dipsticks and moderate or large LE positive dipsticks were each observed in over 50% of the sample in every week. Strong positive dipstick results were observed in 35% to 60% of participants in every week. A, B1, or B2 symptoms co-occurred less than 50% of the time with strong positive dipsticks, but they also co-occurred with negative dipsticks. Participants were asymptomatic with a strong positive dipstick an average of 30.2% of the weeks. On average, 73% of the time a person had a negative dipstick, they also had no key symptoms (95% CI, .597-.865).

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