Asymmetric large for gestational age newborns in pregnancies complicated by diabetes mellitus: is maternal obesity a culprit?.
ISSN:- 1476-4954
- *Diabetes Mellitus, Type 1/co [Complications]
- *Diabetes Mellitus, Type 2/co [Complications]
- *Fetal Macrosomia/ep [Epidemiology]
- *Obesity/co [Complications]
- *Pregnancy Complications
- *Pregnancy in Diabetics
- Adult
- Birth Weight
- Body Mass Index
- Female
- Fetal Macrosomia/et [Etiology]
- Humans
- Infant, Newborn
- Insulin/ad [Administration & Dosage]
- Pregnancy
- Weight Gain
- MedStar Health Research Institute
- MedStar Washington Hospital Center
- Obstetrics and Gynecology/Maternal-Fetal Medicine
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, P.H.S
| Item type | Current library | Collection | Call number | Status | Date due | Barcode | |
|---|---|---|---|---|---|---|---|
| Journal Article | MedStar Authors Catalog | Article | Available | 21957900 |
Available online through MWHC library: 2013 to the present
CONCLUSION: Although there is a known association between obesity and LGA in women with diabetes, we found that overweight and obese women with Type 1 or Type 2 diabetes do not have increased odds of delivering an A-LGA newborn. However, insulin dose in Type 2 diabetes and maternal weight gain in Type 1 diabetes were significantly associated with the odds of delivering an A-LGA neonate.
METHODS: Retrospective analysis of 306 pregnancies complicated by Type 1 and 55 by Type 2 diabetes.
OBJECTIVE: Evaluate the association between body mass index (BMI) and the delivery of an asymmetrically large for gestational age (A-LGA) newborn in women with diabetes.
RESULTS: The prevalence of Type 1 and Type 2 diabetics delivering large for gestational age (LGA) infants was 42% and 49%, respectively. Of these 49% and 55% were A-LGA, respectively. Pre-pregnancy BMI was not associated with increased odds of delivering an A-LGA newborn in women with Type 1 or 2 diabetes. However, in Type 1 diabetics, each one-pound increase in maternal weight during pregnancy resulted in 4% increased odds of delivering an A-LGA newborn. For Type 2 diabetics, the odds of delivering an A-LGA infant was decreased by 10% for each 0.1 unit/kg increase in insulin dose.
English