Asymmetric large for gestational age newborns in pregnancies complicated by diabetes mellitus: is maternal obesity a culprit?.

MedStar author(s):
Citation: Journal of Maternal-Fetal & Neonatal Medicine. 25(1):32-5, 2012 Jan.PMID: 21957900Institution: MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment: Obstetrics and Gynecology/Maternal-Fetal MedicineForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.Subject headings: *Diabetes Mellitus, Type 1/co [Complications] | *Diabetes Mellitus, Type 2/co [Complications] | *Fetal Macrosomia/ep [Epidemiology] | *Obesity/co [Complications] | *Pregnancy Complications | *Pregnancy in Diabetics | Adult | Birth Weight | Body Mass Index | Female | Fetal Macrosomia/et [Etiology] | Humans | Infant, Newborn | Insulin/ad [Administration & Dosage] | Pregnancy | Weight GainLocal holdings: Available online through MWHC library: 2013 to the presentISSN:
  • 1476-4954
Name of journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansAbstract: CONCLUSION: Although there is a known association between obesity and LGA in women with diabetes, we found that overweight and obese women with Type 1 or Type 2 diabetes do not have increased odds of delivering an A-LGA newborn. However, insulin dose in Type 2 diabetes and maternal weight gain in Type 1 diabetes were significantly associated with the odds of delivering an A-LGA neonate.METHODS: Retrospective analysis of 306 pregnancies complicated by Type 1 and 55 by Type 2 diabetes.OBJECTIVE: Evaluate the association between body mass index (BMI) and the delivery of an asymmetrically large for gestational age (A-LGA) newborn in women with diabetes.RESULTS: The prevalence of Type 1 and Type 2 diabetics delivering large for gestational age (LGA) infants was 42% and 49%, respectively. Of these 49% and 55% were A-LGA, respectively. Pre-pregnancy BMI was not associated with increased odds of delivering an A-LGA newborn in women with Type 1 or 2 diabetes. However, in Type 1 diabetics, each one-pound increase in maternal weight during pregnancy resulted in 4% increased odds of delivering an A-LGA newborn. For Type 2 diabetics, the odds of delivering an A-LGA infant was decreased by 10% for each 0.1 unit/kg increase in insulin dose.All authors: Driggers RW, Feghali MN, Khoury JC, Miodovnik M, Shveiky D, Timofeev JDigital Object Identifier: Date added to catalog: 2013-09-17
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article Available 21957900

Available online through MWHC library: 2013 to the present

CONCLUSION: Although there is a known association between obesity and LGA in women with diabetes, we found that overweight and obese women with Type 1 or Type 2 diabetes do not have increased odds of delivering an A-LGA newborn. However, insulin dose in Type 2 diabetes and maternal weight gain in Type 1 diabetes were significantly associated with the odds of delivering an A-LGA neonate.

METHODS: Retrospective analysis of 306 pregnancies complicated by Type 1 and 55 by Type 2 diabetes.

OBJECTIVE: Evaluate the association between body mass index (BMI) and the delivery of an asymmetrically large for gestational age (A-LGA) newborn in women with diabetes.

RESULTS: The prevalence of Type 1 and Type 2 diabetics delivering large for gestational age (LGA) infants was 42% and 49%, respectively. Of these 49% and 55% were A-LGA, respectively. Pre-pregnancy BMI was not associated with increased odds of delivering an A-LGA newborn in women with Type 1 or 2 diabetes. However, in Type 1 diabetics, each one-pound increase in maternal weight during pregnancy resulted in 4% increased odds of delivering an A-LGA newborn. For Type 2 diabetics, the odds of delivering an A-LGA infant was decreased by 10% for each 0.1 unit/kg increase in insulin dose.

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