Genome-wide linkage analysis of carotid artery lumen diameter: the strong heart family study.

MedStar author(s):
Citation: International Journal of Cardiology. 168(4):3902-8, 2013 Oct 9.PMID: 23871337Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., ExtramuralSubject headings: *Carotid Arteries/us [Ultrasonography] | *Carotid Stenosis/ge [Genetics] | *Carotid Stenosis/us [Ultrasonography] | *Genetic Linkage/ge [Genetics] | *Genome-Wide Association Study/mt [Methods] | *Indians, North American | Adult | Arizona/eh [Ethnology] | Carotid Stenosis/eh [Ethnology] | Cohort Studies | Family/eh [Ethnology] | Female | Humans | Indians, North American/eh [Ethnology] | Male | North Dakota/eh [Ethnology] | Oklahoma/eh [Ethnology] | Prospective Studies | South Dakota/eh [Ethnology]ISSN:
  • 0167-5273
Name of journal: International journal of cardiologyAbstract: BACKGROUND: A significant proportion of the variability in carotid artery lumen diameter is attributable to genetic factors.CONCLUSION: We found significant evidence for loci influencing carotid artery lumen diameter on chromosome 7q and suggestive linkage on chromosomes 12q and 9q.Copyright � 2013. Published by Elsevier Ireland Ltd. All rights reserved.METHODS: Carotid ultrasonography and genotyping were performed in the 3300 American Indian participants in the Strong Heart Family Study (SHFS) to identify chromosomal regions harboring novel genes associated with inter-individual variation in carotid artery lumen diameter. Genome-wide linkage analysis was conducted using standard variance component linkage methods, implemented in SOLAR, based on multipoint identity-by-descent matrices.RESULTS: Genome-wide linkage analysis revealed a significant evidence for linkage for a locus for left carotid artery diastolic and systolic lumen diameters in Arizona SHFS participants on chromosome 7 at 120 cM (lod = 4.85 and 3.77, respectively, after sex and age adjustment, and lod = 3.12 and 2.72, respectively, after adjustment for sex, age, height, weight, systolic and diastolic blood pressure, diabetes mellitus and current smoking). Other regions with suggestive evidence of linkage for left carotid artery diastolic and systolic lumen diameter were found on chromosome 12 at 153 cM (lod = 2.20 and 2.60, respectively, after sex and age adjustment, and lod = 2.44 and 2.16, respectively, after full covariate adjustment) in Oklahoma SHFS participants; suggestive linkage for right carotid artery diastolic and systolic lumen diameter was found on chromosome 9 at 154 cM (lod = 2.72 and 3.19, respectively after sex and age adjustment, and lod = 2.36 and 2.21, respectively, after full covariate adjustment) in Oklahoma SHFS participants.All authors: Almasy L, Bella JN, Best LG, Cole SA, Comuzzie A, Devereux RB, Fabsitz RR, Goring HH, Howard BV, Laston S, Lee ET, Maccluer JW, Roman MJDigital Object Identifier: Date added to catalog: 2015-03-17
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article Available 23871337

BACKGROUND: A significant proportion of the variability in carotid artery lumen diameter is attributable to genetic factors.

CONCLUSION: We found significant evidence for loci influencing carotid artery lumen diameter on chromosome 7q and suggestive linkage on chromosomes 12q and 9q.Copyright � 2013. Published by Elsevier Ireland Ltd. All rights reserved.

METHODS: Carotid ultrasonography and genotyping were performed in the 3300 American Indian participants in the Strong Heart Family Study (SHFS) to identify chromosomal regions harboring novel genes associated with inter-individual variation in carotid artery lumen diameter. Genome-wide linkage analysis was conducted using standard variance component linkage methods, implemented in SOLAR, based on multipoint identity-by-descent matrices.

RESULTS: Genome-wide linkage analysis revealed a significant evidence for linkage for a locus for left carotid artery diastolic and systolic lumen diameters in Arizona SHFS participants on chromosome 7 at 120 cM (lod = 4.85 and 3.77, respectively, after sex and age adjustment, and lod = 3.12 and 2.72, respectively, after adjustment for sex, age, height, weight, systolic and diastolic blood pressure, diabetes mellitus and current smoking). Other regions with suggestive evidence of linkage for left carotid artery diastolic and systolic lumen diameter were found on chromosome 12 at 153 cM (lod = 2.20 and 2.60, respectively, after sex and age adjustment, and lod = 2.44 and 2.16, respectively, after full covariate adjustment) in Oklahoma SHFS participants; suggestive linkage for right carotid artery diastolic and systolic lumen diameter was found on chromosome 9 at 154 cM (lod = 2.72 and 3.19, respectively after sex and age adjustment, and lod = 2.36 and 2.21, respectively, after full covariate adjustment) in Oklahoma SHFS participants.

English

Powered by Koha