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Effect of calcium channel blocker on labor curve in pregnant individuals with chronic hypertension.

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Citation: American Journal of Perinatology. 2023 May 19PMID: 37207673Institution: MedStar Washington Hospital CenterDepartment: Obstetrics and GynecologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXED | Year: 2023 ISSN:

0735-1631

Name of journal: American journal of perinatologyAbstract: METHODS: This was a secondary analysis of a retrospective cohort study of individuals with chronic hypertension who underwent vaginal delivery at a tertiary care center from January 2010 to December 2020. We excluded individuals with prior uterine surgeries, and a 5-minute Apgar score of less than 5. We used a repeated-measures regression with a 3rd order polynomial function to compare the average labor curves according to antihypertensive medication. Estimates of the median (5th-95th percentile) traverse times between two dilations were computed using interval-censored regression.OBJECTIVE: To compare the labor progress between individuals who received calcium channel blocker (CCB) and those who did not receive CCB during labor.RESULTS: Of 285 individuals with chronic hypertension, 88 (30.9%) received CCB. Individuals who received CCB during labor compared to those who did not were more likely to deliver at earlier gestational age and to have pregestational diabetes and superimposed preeclampsia (P < 0.01). The progress of labor in the latent phase was not found to be significantly different between both groups (median 11.51 hours vs. 8.74 hours; P = 0.08). However, after stratification by parity, nulliparous individuals who received CCB during labor were more likely to have a longer latent phase of labor (median 14.4 hours vs. 8.5 hours; P = 0.03) Conclusion: A calcium channel blocker may slow the latent phase of labor in individuals with chronic hypertension. Aiming to minimize intrapartum iatrogenic interventions, allowing adequate time for pregnant individuals during the latent phase of labor is especially important if individuals are on a calcium channel blocker. Copyright Thieme. All rights reserved.All authors: Abuhamad AZ, Barake C, Baraki D, Donaldson T, Huang J, Kawakita T, Seagraves EFiscal year: FY2023 Digital Object Identifier:

https://dx.doi.org/10.1055/a-2096-2338

Date added to catalog: 2023-06-28

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Title notes ( 4 )

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	37207673	Available		37207673

METHODS: This was a secondary analysis of a retrospective cohort study of individuals with chronic hypertension who underwent vaginal delivery at a tertiary care center from January 2010 to December 2020. We excluded individuals with prior uterine surgeries, and a 5-minute Apgar score of less than 5. We used a repeated-measures regression with a 3rd order polynomial function to compare the average labor curves according to antihypertensive medication. Estimates of the median (5th-95th percentile) traverse times between two dilations were computed using interval-censored regression.

OBJECTIVE: To compare the labor progress between individuals who received calcium channel blocker (CCB) and those who did not receive CCB during labor.

RESULTS: Of 285 individuals with chronic hypertension, 88 (30.9%) received CCB. Individuals who received CCB during labor compared to those who did not were more likely to deliver at earlier gestational age and to have pregestational diabetes and superimposed preeclampsia (P < 0.01). The progress of labor in the latent phase was not found to be significantly different between both groups (median 11.51 hours vs. 8.74 hours; P = 0.08). However, after stratification by parity, nulliparous individuals who received CCB during labor were more likely to have a longer latent phase of labor (median 14.4 hours vs. 8.5 hours; P = 0.03) Conclusion: A calcium channel blocker may slow the latent phase of labor in individuals with chronic hypertension. Aiming to minimize intrapartum iatrogenic interventions, allowing adequate time for pregnant individuals during the latent phase of labor is especially important if individuals are on a calcium channel blocker. Copyright Thieme. All rights reserved.

English