Hemiplegic Migraine. [Review]

MedStar author(s):
Citation: Current Neurology & Neuroscience Reports. 23(7):381-387, 2023 Jul.PMID: 37247170Department: MedStar Georgetown University Hospital/MedStar Washington Hospital Center | Neurology ResidencyForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Epilepsy | *Migraine Disorders | *Migraine with Aura | Epilepsy/di [Diagnosis] | Hemiplegia/co [Complications] | Hemiplegia/di [Diagnosis] | Humans | Migraine Disorders/di [Diagnosis] | Migraine Disorders/ep [Epidemiology] | Migraine Disorders/ge [Genetics] | Migraine with Aura/di [Diagnosis] | Migraine with Aura/ep [Epidemiology] | Migraine with Aura/ge [Genetics] | Neurons | Year: 2023ISSN:
  • 1528-4042
Name of journal: Current neurology and neuroscience reportsAbstract: PURPOSE OF REVIEW: In this article, we review recent updates to the epidemiology, diagnostic testing, genetics, pathophysiology, and management of hemiplegic migraine.RECENT FINDINGS: While three genes have been historically associated with hemiplegic migraine, recent studies suggest two additional genes may also be implicated including PPRT2 and SLC1A3. Hemiplegic migraine is a severe subset of migraine with aura with symptoms including reversible hemiparesis in addition to other aura symptoms such as visual, sensory, or speech. The exact pathophysiology of hemiplegic migraine is not clear, but it is thought that this phenomenon is due to neuronal and glial depolarization causing cortical spreading depression. Due to the severity of presentation as well as the numerous mimickers, it is important to know a comprehensive differential and work-up. Given the low prevalence of the disease, most studies regarding treatment are limited to case studies. There is still an important need for further and larger studies regarding management of these cases. Copyright © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.All authors: Ailani J, Nandyala A, Shah TFiscal year: FY2024Digital Object Identifier: ORCID: Date added to catalog: 2023-07-27
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Journal Article MedStar Authors Catalog Article 37247170 Available 37247170

PURPOSE OF REVIEW: In this article, we review recent updates to the epidemiology, diagnostic testing, genetics, pathophysiology, and management of hemiplegic migraine.

RECENT FINDINGS: While three genes have been historically associated with hemiplegic migraine, recent studies suggest two additional genes may also be implicated including PPRT2 and SLC1A3. Hemiplegic migraine is a severe subset of migraine with aura with symptoms including reversible hemiparesis in addition to other aura symptoms such as visual, sensory, or speech. The exact pathophysiology of hemiplegic migraine is not clear, but it is thought that this phenomenon is due to neuronal and glial depolarization causing cortical spreading depression. Due to the severity of presentation as well as the numerous mimickers, it is important to know a comprehensive differential and work-up. Given the low prevalence of the disease, most studies regarding treatment are limited to case studies. There is still an important need for further and larger studies regarding management of these cases. Copyright © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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