Temporal Changes in Coronary Plaque as Assessed by an Artificial Intelligence Based Optical Coherence Tomography: From the First-in-Human Trial on DREAMS 3G Scaffold.
Citation: European heart journal cardiovascular Imaging. 2023 Nov 04PMID: 37936296Institution: MedStar Health Research Institute | MedStar Heart & Vascular Institute | MedStar Washington Hospital CenterDepartment: Internal Medicine ResidencyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2023ISSN:- 2047-2404
- Garcia-Garcia, Hector M:
- https://orcid.org/0000-0001-5100-0471
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 37936296 | Available | 37936296 |
AIMS: To assess the impact of the baseline plaque composition on the DREAMS 3G luminal late loss and to compare the serial plaque changes between baseline and 6-month (6 M), and 12-month (12 M) follow-up.
CONCLUSIONS: The larger the fibrous tissue in the lesion at baseline, the larger the luminal loss seen at 6 M and 12 M. Following the implantation of DREAMS 3G, favorable healing of the vessel coronary wall occurs as shown by a decrease in the lipid area and an increase in fibrous tissue. Copyright © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: [email protected].
METHODS AND RESULTS: A total of 116 patients were enrolled in the BIOMAG-I trial. Patients were imaged with optical coherence tomography (OCT) pre- and post-DREAMS 3G implantation and at 6 and 12 months. OCTPlus software uses artificial intelligence to assess composition (i.e., lipid, calcium, fibrous tissue) of the plaque. The differences between the OCT-derived minimum lumen area (MLA) post-percutaneous coronary intervention (PCI) and 12 M, were grouped into 3 terciles. Patients with larger MLA differences at 12 M (p 0.0003) had significantly larger content of fibrous tissue at baseline. There was a reduction of 24.8% and 20.9% in lipid area, both p < 0.001, between the pre-DREAMS 3G OCT and the 6 M and 12 M follow-up. Conversely, the fibrous tissue increased by 48.4% and 36.0% at 6 M and 12 M follow-up, both p < 0.001.
English